Lions vs. Bills Odds & Betting Predictions - September 18, 2026
Lions at Bills
12:15 am • Amazon Prime VideoLions at Bills Odds
Spread, Total, Moneyline
MatchupOpenSpreadTotalMoneyline | ||||
|---|---|---|---|---|
 Lions 1-1 | N/A | N/A | N/A | |
 Bills 2-0 | N/A | N/A | N/A | |
Lions vs. Bills Props
Prop Projections
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Prop Odds Comparison
Line Movement Tracker
Lions vs. Bills Public Betting Percentages
Matchup History
Against the Spread (ATS) History
Over/Under History
Last 5 Matchups
Depth Charts
| Starter | 2ND | 3RD | 4TH | |
|---|---|---|---|---|
| QB | Josh Allen | Mitchell Trubisky | Shane Buechele | |
| RB | James Cook | Ray Davis | Ty Johnson | Frank Gore |
| WR | Khalil Shakir | Stephen Gosnell | ||
| TE | Dalton Kincaid | Dawson Knox | Jackson Hawes | Keleki Latu |
| LT | Dion Dawkins | Tylan Grable | Chase Lundt | Travis Clayton |
| LG | David Edwards | |||
| C | Connor McGovern | Sedrick Van Pran-Granger | ||
| RG | O'Cyrus Torrence | Alec Anderson | ||
| RT | Spencer Brown | Ryan Van Demark | ||
| LDE | Greg Rousseau | Landon Jackson | Javon Solomon | |
| WLB | Matt Milano | Dorian Williams | Keonta Jenkins | |
| MLB | Terrel Bernard | Joe Andreessen | Shaq Thompson | Jimmy Ciarlo |
| LCB | Christian Benford | Maxwell Hairston | Dorian Strong | |
| SS | Cole Bishop | Cam Lewis | Wande Owens | |
| FS | Taylor Rapp | Damar Hamlin | Jordan Hancock | |
| RCB | Tre'Davious White | Dane Jackson | ||
| LS | Reid Ferguson | |||
| LWR | Joshua Palmer | Tyrell Shavers | ||
| DT | Ed Oliver | T.J. Sanders | DeWayne Carter | |
| NT | DaQuan Jones | Deone Walker | Zion Logue | |
| RWR | Keon Coleman | Curtis Samuel | ||
| FB | Reggie Gilliam | |||
| NB | Taron Johnson | |||
| K | Tyler Bass |
Lions vs. Bills Odds Comparison
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Lions at Bills Team Totals
MatchupOverUnder | ||
|---|---|---|
Lions 1-1 | N/A | N/A |
Bills 2-0 | N/A | N/A |