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Lions vs. Bills Odds & Betting Predictions - September 18, 2026

Lions at Bills

12:15 am • Amazon Prime Video

Detroit Lions

9-8
@

Buffalo Bills

1-1

Lions at Bills Odds

Spread, Total, Moneyline

MatchupOpenSpreadTotalMoneyline
Lions
9-8
+3
+3-110
o52.5-115
+140
Bills
1-1
u52.5
-3-110
u52.5-105
-165
location pinFriday 12:15 a.m.
September 18, 2026

Lions vs. Bills Props

Prop Projections

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Prop Odds Comparison

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Line Movement Tracker

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Lions vs. Bills Public Betting Percentages

Away Logo

Lions

Public

Home Logo

Bills

100%

Bets%

0%

Money%

NFL Public Betting Right Arrow

Betting Trends

  • Bills are 4-1 in their last 5 games.
  • Bills are 2-3 in their last 5 games against the spread
  • Bills are 4-4 in their road games against the spread
  • The totals have gone OVER in 4 of Bills' last 5 games
  • The totals have gone OVER in 6 of Bills' 9 last games at home

Matchup History

Against the Spread (ATS) History

overallhomeawayfavoriteunderdog
Bills		8-94-54-46-92-0
Lions		8-94-44-56-52-4

Over/Under History

overallhome o/uaway o/ufavorite o/uunderdog o/u
Bills		9-86-33-58-71-1
Lions		10-76-24-58-32-4

Straight-Up (ML) History

overallhomeawayfavoriteunderdog
Bills		12-5N/AN/A10-52-0
Lions		9-8N/AN/A7-42-4

Last 5 Matchups

dateopponentscorespreadover/undermoneyline
Jan 17th@DENL 30-33+1.5 LO 45.5DEN +105
Jan 11th@JACW 27-24+1.5 WU 51.5BUF +105
Jan 4thNYJW 35-8-13.5 WO 39.5BUF -850
Dec 28thPHIL 12-13-3 LU 45PHI -175
Dec 21st@CLEW 23-20-10.5 LO 41.5BUF -582

Bills vs. Lions Injury Updates

Bills Injuries

  • Ty Johnson
    RB

    Johnson is out with ankle

    Out

  • Mecole Hardman
    WR

    Hardman is out with calf

    Out

  • Tyler Bass
    K

    Bass is out with hip

    Out

  • Joshua Palmer
    WR

    Palmer is out with ankle

    Out

  • Tyrell Shavers
    WR

    Shavers is out with knee

    Out

Lions Injuries

  • Greg Dortch
    WR

    Dortch is out with chest

    Out

  • Brock Wright
    TE

    Wright is out with neck

    Out

  • Isiah Pacheco
    RB

    Pacheco is out with rest

    Out

  • Sam LaPorta
    TE

    LaPorta is out with back

    Out

See more NFL Injuries Right Arrow
Depth Charts
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Starter2ND3RD4TH
QBJosh AllenMitchell TrubiskyShane Buechele
RBJames CookRay DavisTy JohnsonFrank Gore
WRKhalil ShakirStephen Gosnell
TEDalton KincaidDawson KnoxJackson HawesKeleki Latu
LTDion DawkinsTylan GrableChase LundtTravis Clayton
LGDavid Edwards
CConnor McGovernSedrick Van Pran-Granger
RGO'Cyrus TorrenceAlec Anderson
RTSpencer BrownRyan Van Demark
LDEGreg RousseauLandon JacksonJavon Solomon
WLBMatt MilanoDorian WilliamsKeonta Jenkins
MLBTerrel BernardJoe AndreessenShaq ThompsonJimmy Ciarlo
LCBChristian BenfordMaxwell HairstonDorian Strong
SSCole BishopCam LewisWande Owens
FSTaylor RappDamar HamlinJordan Hancock
RCBTre'Davious WhiteDane Jackson
LSReid Ferguson
LWRJoshua PalmerTyrell Shavers
DTEd OliverT.J. SandersDeWayne Carter
NTDaQuan JonesDeone WalkerZion Logue
RWRKeon ColemanCurtis Samuel
FBReggie Gilliam
NBTaron Johnson
KTyler Bass

Lions vs. Bills Odds Comparison

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Lions at Bills Team Totals

MatchupOverUnder
Lions
9-8
N/A
N/A
Bills
1-1
N/A
N/A