Astros vs. Angels Odds & Betting Predictions - September 28, 2025

Astros at Angels

7:07 pm • SCHN

Houston Astros

87-75

6 - 2

Los Angeles Angels

72-90

pitcher		team	era	w-l
S.Aldegheri			7.90	0-2
L.McCullers			6.51	2-5

MatchupOpenSpreadTotalMoneyline
Astros 87-75	-1.5	-1.5+134	o9-104	-117
Angels 72-90	u9.5	+1.5-164	u9-112	-102

Sunday 7:07 p.m.

September 28, 2025

Angel StadiumAnaheim

L.McCullers o3.5 Ks+128

1.28u

McCullers will make his return in what will be a meaningless game for Houston. He might not go more than 4-5 innings, but that’s plenty in this matchup. The Angels are the highest-strikeout team in the league vs. RHP and they’ve ramped it up in September. LA has an absurd 32.2% K% vs. RHP this month.

No props found

MLB Public Betting

Angels are 2-3 in their last 5 games.
Angels are 2-3 in their last 5 games against the spread
Angels are 41-40 in their road games against the spread
The totals have gone OVER in 1 of Angels' last 5 games
The totals have gone OVER in 44 of Angels' 81 last games at home

Against the Spread (ATS) History

	overall	home	away	favorite	underdog
Angels	85-77	44-37	41-40	13-25	70-52
Astros	82-80	37-44	45-36	43-60	39-18

Over/Under History

	overall	home o/u	away o/u	favorite o/u	underdog o/u
Angels	86-72-4	44-34-3	42-38-1	21-16-1	64-55-3
Astros	72-83-7	36-43-2	36-40-5	45-56-2	25-27-5

Straight-Up (ML) History

	overall	home	away	favorite	underdog
Angels	72-90	39-42	33-48	19-19	51-71
Astros	87-75	46-35	41-40	56-47	31-26

date	opponent	score	spread	over/under	moneyline
Sep 28th	HOU	L 1-6	+1.5 L	U 9	HOU +121
Sep 27th	HOU	W 4-3	+1.5 W	U 9	LAA +110
Sep 26th	KC	L 4-9	+1.5 L	O 9.5	KC +112
Sep 25th	KC	W 3-2	+1.5 W	U 8.5	LAA -106
Sep 24th	KC	L 4-8	+1.5 L	O 9	KC +140

Anthony Rendon
3B
Rendon is out with hip
Out
Gustavo Campero
RF
Campero is out with ankle
Out

Pedro Leon
RF
Leon is out with knee
Out
Hayden Wesneski
RP
Wesneski is out with elbow
Out

See more MLB Injuries

PITCHER	PC	IP	K	ER
RL.McCullers, P	54	3	4	1
LC.Gordon, P	68	5	3	0
RJ.Murray, P	24	1	2	1

HITTERS	H-AB	R	HR	RBI
1Z.Cole, LF	0-4	0	0	0
2M.Dubon, SS	1-5	1	0	0
3V.Caratini, 1B	1-4	1	1	1
4Y.Diaz, C	2-5	1	1	2
5J.Sanchez, DH	2-5	0	0	0
6C.Smith, RF	1-4	1	0	0
7R.Urias, 3B	1-3	1	1	2
8B.Matthews, 2B	2-4	1	1	1
9J.Melton, CF	1-3	0	0	0

PITCHER	PC	IP	K	ER
LS.Aldegheri, P	96	4.2	5	4
RC.Brogdon, P	27	1.1	2	2
RR.Zeferjahn, P	21	1	1	0
RS.Bachman, P	12	1	0	0
LS.Peralta, P	13	1	1	0

HITTERS	H-AB	R	HR	RBI
1L.Rengifo, 3B	0-4	0	0	0
2M.Trout, DH	1-1	1	1	1
2L.O'Hoppe, PH	0-3	0	0	0
2L.O'Hoppe, DH	0-3	0	0	0
3J.Adell, RF	1-4	1	0	0
4C.Taylor, LF	1-3	0	0	0
5C.Moore, 2B	0-4	0	0	0
6C.Kieboom, 1B	1-4	0	0	1
7S.Rivero, C	1-4	0	0	0
8D.Guzman, SS	1-4	0	0	0
9B.Teodosio, CF	0-2	0	0	0
9T.Ward, PH	0-1	0	0	0