Mariners vs. Guardians Odds & Betting Predictions - March 21, 2026

Mariners at Guardians

1:05 am • SEAM

Seattle Mariners

@

Cleveland Guardians

pitcher		team	era	w-l

MatchupOpenSpreadTotalMoneyline
Mariners 7-17	N/A	N/A	N/A
Guardians 12-12	N/A	N/A	N/A

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Saturday 1:05 a.m.

March 21, 2026

Goodyear BallparkGoodyear

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MLB Public Betting

Guardians are 3-2 in their last 5 games.
Guardians are 1-4 in their last 5 games against the spread
Guardians are 47-34 in their road games against the spread
The totals have gone OVER in 2 of Guardians' last 5 games
The totals have gone OVER in 37 of Guardians' 81 last games at home

Against the Spread (ATS) History

	overall	home	away	favorite	underdog
Guardians	86-76	39-42	47-34	33-36	51-38
Mariners	69-93	36-45	33-48	44-69	24-22

Over/Under History

	overall	home o/u	away o/u	favorite o/u	underdog o/u
Guardians	69-87-6	37-41-3	32-46-3	34-34-1	34-50-5
Mariners	88-68-6	41-35-5	47-33-1	58-49-6	28-18

Straight-Up (ML) History

	overall	home	away	favorite	underdog
Guardians	88-74	45-36	43-38	44-25	43-46
Mariners	90-72	51-30	39-42	66-47	22-24

date	opponent	score	spread	over/under	moneyline
Mar 18th	@CIN	W 8-6	+1.5 W	O 11.5	CLE +114
Mar 17th	CHC	L 2-5	-1.5 L	U 9.5	CHC -120
Mar 15th	ATH	W 12-6	-1.5 W	O 11.5	CLE -152
Mar 14th	@SD	L 5-8	-	-	-
Mar 13th	@LAA	L 2-5	+1.5 L	U 12.5	LAA +118

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MatchupOverUnder
Mariners 7-17	N/A	N/A
Guardians 12-12	N/A	N/A