Cavaliers vs 76ers Odds & Live Scores - October 22, 2026 | The Action Network

Cavaliers at 76ers

11:00 pm • ESPN

Cleveland Cavaliers

@

Philadelphia 76ers

MatchupOpenSpreadTotalMoneyline
Cavaliers 1-1	+4.5	+4-112	o233.5-110	+130
76ers 1-2	u233.5	-4-107	u233.5-110	-155

location pin

Thursday 11:00 p.m.

October 22, 2026

Xfinity Mobile ArenaPhiladelphia

Loading props…

NBA Public Betting

76ers are 2-3 in their last 5 games.
76ers are 1-4 in their last 5 games against the spread
76ers are 24-16 in their road games against the spread
The totals have gone OVER in 1 of 76ers' last 5 games
The totals have gone OVER in 20 of 76ers' 41 last games at home

Against the Spread (ATS) History

	overall	home	away	favorite	underdog
76ers	43-38-1	19-22	24-16-1	27-17	16-21-1
Cavaliers	33-49	16-25	17-24	24-42	9-7

Over/Under History

	overall	home o/u	away o/u	favorite o/u	underdog o/u
76ers	40-42	20-21	20-21	25-19	15-23
Cavaliers	40-41-1	17-24	23-17-1	33-32-1	7-9

Straight-Up (ML) History

	overall	home	away	favorite	underdog
76ers	45-37	N/A	N/A	34-10	11-27
Cavaliers	52-30	N/A	N/A	45-21	7-9

date	opponent	score	spread	over/under	moneyline
Oct 11th	@BOS	L 106-144	+8 L	O 225	BOS +220
Oct 8th	@BKN	L 108-114	-8.5 L	O 220.5	BKN -298
Oct 5th	NYK	W 120-97	+4.5 W	U 228.5	PHI +160
Jul 18th	@MIL	L 94-96	+6.5 W	O 188.5	MIL +190
Jul 15th	ORL	L 92-99	+7.5 W	O 182.5	ORL +235

Kentavious Caldwell-Pope
SG
Caldwell-Pope is out with finger
Out
Anfernee Simons
SG
Anfernee Simons (wrist) out Monday.
Out

Rayan Rupert
SG
Rupert is questionable
Questionable

Peyton Watson
SF
Watson is out with hamstring
Out

Jaylon Tyson
SG
Jaylon Tyson (toe) probable Friday.
Probable

See more NBA Injuries

Could not load odds

See more NBA Odds

MatchupOverUnder
Cavaliers 1-1	N/A	N/A
76ers 1-2	N/A	N/A