Louisville vs. Ole Miss Odds & Betting Predictions - September 6, 2026

The last time we saw Ole Miss, the Rebels were on a run to the College Football Final Four. Trinidad Chambliss carved up Tulane and Georgia before nearly dragging Mississippi to its first bowl game with national title implications in 63 years. With Chambliss and company still basking in the glow of a dream season, it’s easy to overlook a few key details when it comes to Ole Miss. The Rebels played in a lot of close contests, finishing 6-2 straight up in one-possession games. They also rode the emotion of the Lane Kiffin circus perfectly. Pete Golding and offensive coordinator Charlie Weis Jr. pushed all the right buttons emotionally and tactically during their playoff run. But Weis Jr. has reunited with Kiffin in Baton Rouge. John David Baker takes over playcalling duties with an entirely new receiving corps. A slower-than-usual start for Chambliss and the Ole Miss offense wouldn’t surprise me at all. As for the Louisville side of things, this is an auto-bet situation. When Jeff Brohm is catching points, you back him. Dating back to his time at Purdue, Brohm is 26-15-1 ATS (63.4%) as an underdog, making him one of the most profitable Power Four coaches in the past nine years. He returns All-American caliber playmakers on both sides of the ball in Isaac Brown and Clev Lubin. Brown’s career yards per carry average of 7.7 is otherworldly, and Lubin averaged more than one tackle for loss per game last season. If transfer quarterback Lincoln Kienholz hits the ground running, we’ll have a four-quarter battle in the Music City. Keep in mind, Kienholz battled Julian Sayin for the starting role at Ohio State last offseason after a decorated high school career. The four-star talent, in the hands of Brohm and the UL staff, could be a breakout star. It’s time to nab Louisville before this line ducks below a full touchdown.

Vintage Brohm spot