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NFL PrizePicks, Underdog Plays for Thursday Night Football on September 25

NFL PrizePicks, Underdog Plays for Thursday Night Football on September 25 article feature image
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Pictured: Kyler Murray.(Credit: Cary Edmondson-Imagn Images)

Thursday Night Football for NFL Week 4 on September 25 showcases a marquee matchup as the Cardinals battle the Seahawks.

For my top NFL PrizePicks and Underdog plays, I’m spotlighting Kyler Murray, Trey McBride, and Michael Wilson under the lights.


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Kyler Murray

More Than 208.5 Passing Yards

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The loss of starting running back James Conner looms large for the Cardinals.

While the expectation is that Trey Benson will step into the bell-cow role, the transition may not be seamless, leaving this game on the shoulders of quarterback Kyler Murray.

Murray has not had the best start to the season through the air as he's only averaging 181 yards passing per game. However, given the questions surrounding their rushing attack, we should see an uptick in passing volume against a Seahawks secondary that ranks 22nd in opponent completion percentage and 20th in passing yards allowed per game.

Murray surpassed this total 59 percent of the time in 2024, averaging 226 yards per game. Look for him to get closer to that total tonight.


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Trey McBride

Less Than 65.5 Receiving Yards

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Despite expecting an uptick in Murray's passing yards, I'm fading his top target, Trey McBride.

The Cardinals' tight end has garnered 27 percent of the target share and has a good matchup against the Seahawks, but there are some concerns.

Seattle is going to make someone else beat them tonight as McBride thrashed them for over 200 yards receiving in the two meetings last season. We should expect the Seahawks to do everything they can to force Murray to throw to the outside.

Building off that, McBride's aDOT is just 6.1 yards this season. The sure-handed tight end has become more of a safety valve for Murray, rather than the field-stretcher up the seams like we saw last season.


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Michael Wilson

More Than 0.5 Touchdowns

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Lastly, to finish off our targeting of the Cardinals' passing game, we turn to wide receiver Michael Wilson.

Wilson is a big target for Murray and plays opposite Marvin Harrison Jr.

Wilson is often overlooked in this offense, but with McBride contained, Wilson should get more looks, especially in the red zone. Add Wilson to score as your final pick to increase your multiplier, as he's being undervalued in this matchup.

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About the Author

Doug is a college football, college basketball and MLB contributor at the Action Network. He produces content centered around actionable advice with the goal of helping readers become better bettors. He studied journalism at Rutgers and has previously covered the New York Mets, Indianapolis Colts, and Mid-Atlantic region for Perfect Game.

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