Panthers vs. Senators Odds & Betting Predictions - October 21, 2026

Panthers at Senators

11:30 pm • ESPN+
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Panthers at Senators Odds

Spread, Total, Moneyline

MatchupOpenSpreadTotalMoneyline
Panthers
4-2-2
N/A
N/A
N/A
Senators
6-2-0
N/A
N/A
N/A
location pinWednesday 11:30 p.m.
October 21, 2026
Canadian Tire CentreOttawa

Prop Odds Comparison

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Line Movement Tracker

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Panthers vs. Senators Public Betting Percentages

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Panthers

Public

50%

Bets%

50%

Money%

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Matchup History

Against the Spread (ATS) History

overallhomeawayfavoriteunderdog
Senators
3-50-43-11-32-2
Panthers
2-60-22-40-52-1

Over/Under History

overallhome o/uaway o/ufavorite o/uunderdog o/u
Senators
2-61-31-30-42-2
Panthers
3-50-23-31-42-1

Straight-Up (ML) History

overallhomeawayfavoriteunderdog
Senators
6-2N/AN/A4-02-2
Panthers
4-2N/AN/A2-32-1

Last 5 Matchups

dateopponentscorespreadover/undermoneyline
Oct 15thNYIW 2-1-1.5 LU 5.5OTT -163
Oct 13thSTLL 2-7+1.5 LO 5.5STL +106
Oct 12th@NJW 4-1+1.5 WU 5.5OTT -104
Oct 10thNSHW 3-2-1.5 LU 6OTT -176
Oct 8thPHIW 2-1-1.5 LU 5.5OTT -181

Senators vs. Panthers Injury Updates

Senators Injuries

  • William Eklund
    LW

    Eklund is out with ankle

    Out

  • Nikolas Matinpalo
    D

    Matinpalo is out with upper body

    Out

Panthers Injuries

  • Jacob Markstrom
    G

    Markstrom is day-to-day with undisclosed

    Day-to-Day

  • Brad Marchand
    F

    Marchand is out with leg

    Out

  • Radko Gudas
    D

    Gudas is day-to-day with undisclosed

    Day-to-Day

  • Aleksander Barkov
    C

    Barkov is out with lower body

    Out

  • Jonah Gadjovich
    LW

    Gadjovich is out with upper body

    Out

Team Stats
2.75
Goals
2.63
2.63
Goals Against
2.38
5.13
Penalties
4.75
28.38
Shots
22.63
32.63
Hits
24.25

Panthers vs. Senators Odds Comparison

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Panthers at Senators Team Totals

MatchupOverUnder
Panthers
4-2-2
N/A
N/A
Senators
6-2-0
N/A
N/A