Astros vs. Guardians Odds & Betting Predictions - April 22, 2026
Astros at Guardians
5:10 pm • SCHNStarting Pitchers
| pitcher | team | era | w-l | |
|---|---|---|---|---|
 |  | 3.81 | 4-11 | |
 |  | 3.06 | 8-5 |
Astros at Guardians Odds
Spread, Total, Moneyline
MatchupOpenSpreadTotalMoneyline | ||||
|---|---|---|---|---|
Astros 58-56 | +1.5 | +1.5-155 | o8-113 | +136 |
Guardians 57-56 | u8 | -1.5+129 | u8-102 | -162 |
Progressive FieldCleveland
Astros vs. Guardians Expert Picks
Picks Office
Last 30d: 69-63-2 (-1.7u)
CLE -1-110
1u
Join Discord. All picks posted before 8am https://discord.gg/HjKxYKdSUy
Wags Wins
Last 30d: 206-190-5 (-1.0u)
HOU +135
2.03u
Sean Koerner🔮
Last 30d: 30-33-0 (+2.3u)
P.Lambert u4.5 Hits Allowed-114
0.5u
Proj closer to -140
Ryan Minion
Last 30d: 196-308-13 (-109.5u)
Y.Alvarez o1.5 Total Bases+106
$1.06
Grant Neiffer
Last 30d: 17-73-5 (-0.2u)
Y.Alvarez o0.5 HR+370
0.93u
Frank Ammirante
Last 30d: 342-355-13 (-18.7u)
P.Lambert u2.5 BB-193
1.93u
OldSchool0909
Last 30d: 45-72-0 (-14.9u)
HOU +120
1.2u
Frank Ammirante
Last 30d: 342-355-13 (-18.7u)
Under 4.5 (F5)-130
1u
P.Lambert o3.5 Ks-168
1u
Doug Ziefel
Last 30d: 83-98-6 (-4.2u)
CLE -135
0.68u
Astros vs. Guardians Previews & Analysis
Prop Odds Comparison
Line Movement Tracker
Astros vs. Guardians Public Betting Percentages
Betting Trends
- Guardians are 2-3 in their last 5 games.
- Guardians are 2-3 in their last 5 games against the spread
- Guardians are 30-27 in their road games against the spread
- The totals have gone OVER in 1 of Guardians' last 5 games
- The totals have gone OVER in 28 of Guardians' 56 last games at home
Matchup History
Against the Spread (ATS) History
Over/Under History
Last 5 Matchups
Astros vs. Guardians Box Score
Astros Player Stats| PITCHER | PC | IP | K | ER | |
|---|---|---|---|---|---|
 | 96 | 6 | 8 | 0 | |
 | 17 | 1 | 1 | 0 | |
 | 16 | 0.2 | 0 | 0 | |
 | 24 | 1.1 | 1 | 0 |
| HITTERS | H-AB | R | HR | RBI |
|---|---|---|---|---|
 | 1-4 | 1 | 0 | 0 |
 | 3-4 | 1 | 1 | 2 |
 | 0-4 | 0 | 0 | 0 |
 | 1-3 | 0 | 0 | 0 |
 | 1-4 | 0 | 0 | 0 |
 | 0-4 | 0 | 0 | 0 |
 | 0-4 | 0 | 0 | 0 |
 | 0-3 | 0 | 0 | 0 |
 | 0-2 | 0 | 0 | 0 |
Guardians Player Stats| PITCHER | PC | IP | K | ER | |
|---|---|---|---|---|---|
 | 95 | 6 | 3 | 2 | |
 | 18 | 1 | 2 | 0 | |
 | 5 | 1 | 0 | 0 | |
 | 17 | 1 | 1 | 0 |
| HITTERS | H-AB | R | HR | RBI |
|---|---|---|---|---|
 | 1-3 | 0 | 0 | 0 |
 | 2-4 | 0 | 0 | 0 |
 | 1-4 | 0 | 0 | 0 |
 | 0-2 | 0 | 0 | 0 |
 | 0-1 | 0 | 0 | 0 |
| 0-1 | 0 | 0 | 0 |
 | 0-4 | 0 | 0 | 0 |
 | 1-3 | 0 | 0 | 0 |
 | 0-3 | 0 | 0 | 0 |
 | 0-1 | 0 | 0 | 0 |
 | 0-3 | 0 | 0 | 0 |
 | 0-4 | 0 | 0 | 0 |
Astros vs. Guardians Odds Comparison
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Astros at Guardians Team Totals
MatchupOverUnder | ||
|---|---|---|
Astros 58-56 | N/A | N/A |
Guardians 57-56 | N/A | N/A |