Astros vs. Guardians Odds & Betting Predictions - April 22, 2026

Astros at Guardians

5:10 pm • SCHN

Houston Astros

@

Cleveland Guardians

pitcher		team	era	w-l
T.Bibee			0.00	0-0
L.McCullers			0.00	0-0

MatchupOpenSpreadTotalMoneyline
Astros 9-15	N/A	N/A	N/A
Guardians 13-11	N/A	N/A	N/A

location pin

Wednesday 5:10 p.m.

April 22, 2026

Progressive FieldCleveland

thermometer image

58°Fahrenheit

rain image

0%Rain

wind image

6Wind

No props found

MLB Public Betting

Guardians are 3-2 in their last 5 games.
Guardians are 3-2 in their last 5 games against the spread
Guardians are 6-7 in their road games against the spread
The totals have gone OVER in 3 of Guardians' last 5 games
The totals have gone OVER in 5 of Guardians' 11 last games at home

Against the Spread (ATS) History

	overall	home	away	favorite	underdog
Guardians	14-10	8-3	6-7	6-4	8-6
Astros	9-15	6-7	3-8	4-11	5-3

Over/Under History

	overall	home o/u	away o/u	favorite o/u	underdog o/u
Guardians	12-12	5-6	7-6	5-5	7-7
Astros	16-7-1	9-4	7-3-1	9-6	6-1-1

Straight-Up (ML) History

	overall	home	away	favorite	underdog
Guardians	13-11	7-4	6-7	6-4	7-7
Astros	9-15	7-6	2-9	5-10	4-4

date	opponent	score	spread	over/under	moneyline
Apr 20th	HOU	L 2-9	-1.5 L	O 7.5	HOU -135
Apr 19th	BAL	W 8-4	+1.5 W	O 6.5	CLE -120
Apr 18th	BAL	W 4-2	-1.5 W	U 7.5	CLE -146
Apr 17th	BAL	L 4-6	-1.5 L	O 8	BAL -141
Apr 16th	BAL	W 4-2	-1.5 W	U 8	CLE -136

Zach Dezenzo
LF
Dezenzo is out with elbow
Out

See more MLB Injuries

Could not load odds

See more MLB Odds

MatchupOverUnder
Astros 9-15	N/A	N/A
Guardians 13-11	N/A	N/A