Astros vs. Guardians Odds & Betting Predictions - April 21, 2026

Astros at Guardians

10:10 pm • CLEG

Houston Astros

@

Cleveland Guardians

pitcher		team	era	w-l
P.Messick			0.00	0-0
S.Arrighetti			0.00	0-0

MatchupOpenSpreadTotalMoneyline
Astros 8-14	N/A	N/A	N/A
Guardians 12-10	N/A	N/A	N/A

location pin

Tuesday 10:10 p.m.

April 21, 2026

Progressive FieldCleveland

thermometer image

63°Fahrenheit

rain image

0%Rain

wind image

12Wind

No props found

MLB Public Betting

Guardians are 2-3 in their last 5 games.
Guardians are 2-3 in their last 5 games against the spread
Guardians are 6-7 in their road games against the spread
The totals have gone OVER in 2 of Guardians' last 5 games
The totals have gone OVER in 3 of Guardians' 9 last games at home

Against the Spread (ATS) History

	overall	home	away	favorite	underdog
Guardians	13-9	7-2	6-7	5-3	8-6
Astros	8-14	6-6	2-8	4-10	4-3

Over/Under History

	overall	home o/u	away o/u	favorite o/u	underdog o/u
Guardians	10-12	3-6	7-6	3-5	7-7
Astros	14-7-1	8-4	6-3-1	8-6	5-1-1

Straight-Up (ML) History

	overall	home	away	favorite	underdog
Guardians	12-10	6-3	6-7	5-3	7-7
Astros	8-14	7-5	1-9	5-9	3-4

date	opponent	score	spread	over/under	moneyline
Apr 18th	BAL	W 4-2	-1.5 W	U 7.5	CLE -146
Apr 17th	BAL	L 4-6	-1.5 L	O 8	BAL -141
Apr 16th	BAL	W 4-2	-1.5 W	U 8	CLE -136
Apr 15th	@STL	L 3-5	-	U 9	STL -112
Apr 14th	@STL	L 5-6	-1.5 L	O 9	STL -120

Zach Dezenzo
LF
Dezenzo is out with elbow
Out

See more MLB Injuries

Could not load odds

See more MLB Odds

MatchupOverUnder
Astros 8-14	N/A	N/A
Guardians 12-10	N/A	N/A