Astros vs. Guardians Odds & Betting Predictions - April 20, 2026

Astros at Guardians

10:10 pm • CLEG
9 - 2
Starting Pitchers
pitcherteameraw-l
Slade Cecconi logoS.CecconiCleveland Guardians logo4.784-7
Spencer Arrighetti logoS.ArrighettiHouston Astros logo4.607-5

Astros at Guardians Odds

Spread, Total, Moneyline

MatchupOpenSpreadTotalMoneyline
Astros
58-56
+1.5
+1.5-188
o7.5-112
+115
Guardians
57-56
u8.5
-1.5+161
u7.5-108
-135
location pinMonday 10:10 p.m.
April 20, 2026
Progressive FieldCleveland
Astros vs. Guardians Expert Picks
Picks Office
Picks Office
Last 30d: 69-63-2 (-1.7u)
CLE -125
1u
Join Discord. All picks posted before 8am https://discord.gg/HjKxYKdSUy
Sean Zerillo
Sean Zerillo
Last 30d: 119-118-10 (-2.9u)
HOU +115
0.58u
Bet to +108
Wags Wins
Wags Wins
Last 30d: 207-190-5 (-0.0u)
HOU +115
1.44u
Scott Rickenbach
Scott Rickenbach
Last 30d: 63-59-1 (-2.8u)
CLE -114
1u
OldSchool0909
Last 30d: 45-76-0 (-18.9u)
HOU +102
1.02u
Picks Office
Picks Office
Last 30d: 69-63-2 (-1.7u)
Under 7.5-115
1u
Join Discord. All picks posted before 8am https://discord.gg/HjKxYKdSUy
Grant Neiffer
Grant Neiffer
Last 30d: 17-73-5 (-0.2u)
Y.Alvarez o0.5 HR+450
0.25u
Payoff Pitch Podcast
Payoff Pitch Podcast
Last 30d: 34-77-4 (-10.4u)
Under 8-118
0.25u
@Tannerstruth ⭐️ https://myaction.app/CL26XueLu2b
Derek Carty
Derek Carty
Last 30d: 29-21-4 (+26.1u)
S.Arrighetti u4.5 Ks+125
1.25u
There is a value opportunity on Spencer Arrighetti's strikeouts prop. THE BAT X is projecting him to record 4.38 strikeouts, while oddsmakers are implying 4.97. The model believes there is a 56% chance he records fewer than 5 strikeouts, so there is value on the under at +125. This play is good down to at least +106. Love THE BAT X? Get all of Carty's sports betting projections at EV Analytics https://evanalytics.com/subscribe/mlb?ref=zdlkmgz
Doug Ziefel
Doug Ziefel
Last 30d: 87-99-6 (-2.6u)
S.Cecconi u4.5 Hits Allowed+105
0.48u
Frank Ammirante
Frank Ammirante
Last 30d: 347-357-13 (-15.0u)
Under 7.5+100
1u
Sean Zerillo
Sean Zerillo
Last 30d: 119-118-10 (-2.9u)
Under 8.5-128
0.64u
Bet to 7.5 (-102)
Cam Is Money
Cam Is Money
Last 30d: 0-0-0 (+0.0u)
CLE -109
1.09u

Astros vs. Guardians Previews & Analysis

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    Astros vs Guardians: Pure Weather Under

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  • Grant's 5 Home Run Bets for Monday article feature image

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Prop Odds Comparison

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Line Movement Tracker

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Astros vs. Guardians Public Betting Percentages

Away Logo

Astros

Public

31%

Bets%

69%

Money%

Matchup History

Against the Spread (ATS) History

overallhomeawayfavoriteunderdog
Guardians
57-5627-2930-2726-3631-17
Astros
57-5728-2929-2816-2539-29

Over/Under History

overallhome o/uaway o/ufavorite o/uunderdog o/u
Guardians
52-6128-2824-3330-3221-27
Astros
59-49-631-24-228-25-423-17-135-28-5

Straight-Up (ML) History

overallhomeawayfavoriteunderdog
Guardians
57-5628-2829-2832-3025-23
Astros
58-5629-2829-2820-2136-32

Last 5 Matchups

dateopponentscorespreadover/undermoneyline
Apr 19thBALW 8-4+1.5 WO 6.5CLE -120
Apr 18thBALW 4-2-1.5 WU 7.5CLE -146
Apr 17thBALL 4-6-1.5 LO 8BAL -141
Apr 16thBALW 4-2-1.5 WU 8CLE -136
Apr 15th@STLL 3-5-U 9STL -112
Astros vs. Guardians Box Score
Astros Player Stats
Projected
PITCHERPCIPKER
Spencer Arrighetti logoRS.Arrighetti, P96532
Steven Okert logoLS.Okert, P15100
AJ Blubaugh logoRA.Blubaugh, P15110
Jayden Murray logoRJ.Murray, P39220
HITTERSH-ABRHRRBI
Carlos Correa logo1C.Correa, SS3-5102
Yordan Alvarez logo2Y.Alvarez, DH1-5000
Jose Altuve logo3J.Altuve, 2B0-5000
Christian Walker logo4C.Walker, 1B3-5312
Isaac Paredes logo5I.Paredes, 3B3-5222
Taylor Trammell logo6T.Trammell, CF1-1000
Cam Smith logo6C.Smith, PR0-2101
Cam Smith logo6C.Smith, RF0-2101
Yainer Diaz logo7Y.Diaz, C1-4001
Dustin Harris logo8D.Harris, RF0-3100
Dustin Harris logo8D.Harris, LF0-3100
Brice Matthews logo9B.Matthews, LF1-3101
Brice Matthews logo9B.Matthews, CF1-3101
Guardians Player Stats
Projected
PITCHERPCIPKER
Slade Cecconi logoRS.Cecconi, P94526
Matt Festa logoRM.Festa, P22211
Tim Herrin logoLT.Herrin, P19100
Connor Brogdon logoRC.Brogdon, P19111
HITTERSH-ABRHRRBI
Steven Kwan logo1S.Kwan, CF0-4000
Chase DeLauter logo2C.DeLauter, RF0-4000
Jose Ramirez logo3J.Ramirez, 3B1-4200
Kyle Manzardo logo4K.Manzardo, 1B1-5000
Rhys Hoskins logo5R.Hoskins, DH2-4001
George Valera logo6G.Valera, LF1-3001
Juan Brito logo7J.Brito, 2B0-3000
Bo Naylor logo8B.Naylor, C0-4000
Brayan Rocchio logo9B.Rocchio, SS3-3000

Astros vs. Guardians Odds Comparison

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Astros at Guardians Team Totals

MatchupOverUnder
Astros
58-56
N/A
N/A
Guardians
57-56
N/A
N/A