Cubs vs. Red Sox Odds & Betting Predictions - September 25, 2026

Cubs at Red Sox

5:05 pm • MARQ
@
Starting Pitchers
pitcherteameraw-l
Alec Gamboa logoA.GamboaBoston Red Sox logo1.161-0
Clay Holmes logoC.HolmesChicago Cubs logo4.262-4

Cubs at Red Sox Odds

Spread, Total, Moneyline

MatchupOpenSpreadTotalMoneyline
Cubs
88-71
-1.5
-1.5+142
o6.5-105
-125
Red Sox
85-74
u6.5
+1.5-172
u6.5-115
+105
location pinFriday 5:05 p.m.
September 25, 2026
Fenway ParkBoston
thermometer image65°Fahrenheit
rain image0%Rain
wind image16Wind
Cubs vs. Red Sox Expert Picks
Topper
Topper
Last 30d: 186-176-3 (-1.0u)
Under 6.5-115
1u
Flatline Unders (***) Overall: 431-306-44,58% (ROI:12%) Season:16-12-1,57% (ROI:11%) #TSA

Cubs vs. Red Sox Previews & Analysis

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    Opening Pitch: Find Friday's Best Bets Using BARTOLO

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    Sep 25, 2026 UTC
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    +370, +470, +500 and +600 HR Picks on Friday

    Carlos Avilan•
    Sep 25, 2026 UTC
  • Weather-Based Pick for Cubs vs Red Sox Game 1 article feature image

    Weather-Based Pick for Cubs vs Red Sox Game 1

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Prop Odds Comparison

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Line Movement Tracker

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Cubs vs. Red Sox Public Betting Percentages

Away Logo

Cubs

Public

63%

Bets%

37%

Money%

Matchup History

Against the Spread (ATS) History

overallhomeawayfavoriteunderdog
Red Sox
74-8533-4541-4048-6425-21
Cubs
76-8334-4742-3648-6227-20

Over/Under History

overallhome o/uaway o/ufavorite o/uunderdog o/u
Red Sox
70-85-434-41-336-44-151-58-319-26-1
Cubs
88-70-145-35-143-3561-48-126-21

Straight-Up (ML) History

overallhomeawayfavoriteunderdog
Red Sox
85-7439-3946-3561-5123-23
Cubs
88-7146-3542-3663-4723-24

Last 5 Matchups

dateopponentscorespreadover/undermoneyline
Sep 24thCLEL 0-1-1.5 LU 6.5CLE -130
Sep 23rdCLEW 1-0-1.5 LU 6.5BOS -142
Sep 22ndCLEL 2-3-1.5 LU 6.5CLE -121
Sep 20th@TBL 1-5+1.5 LU 7.5TB +126
Sep 19th@TBL 1-2+1.5 WU 7.5TB +125

Red Sox vs. Cubs Injury Updates

Red Sox Injuries

  • Tanner Houck
    SP

    Houck is out with arm

    Out

  • Triston Casas
    1B

    Casas is out with knee

    Out

  • Kutter Crawford
    SP

    Crawford is out with wrist

    Out

Cubs Injuries

  • Tyler Austin
    1B

    Austin is out with knee

    Out

  • Justin Steele
    SP

    Steele is out with elbow

    Out

Cubs vs. Red Sox Starting Lineups
Cubs Starting Lineup
Projected
PITCHERW-LERAWHIPK/9
Clay Holmes logoRC.Holmes, P2-44.261.2416.09
HITTERSAVGOBPSLGHR
Pete Crow-Armstrong logo1P.Crow-Armstrong, CF.280.373.57545
Seiya Suzuki logo2S.Suzuki, RF.270.366.47626
Alex Bregman logo3A.Bregman, DH.262.352.45226
Tyrone Taylor logo4T.Taylor, LF.343.387.4931
Nico Hoerner logo5N.Hoerner, 2B.264.318.3538
Matt Shaw logo6M.Shaw, 3B.232.323.4095
Michael Busch logo7M.Busch, 1B.239.351.39320
Dansby Swanson logo8D.Swanson, SS.216.300.40419
Miguel Amaya logo9M.Amaya, C.231.335.3656
Red Sox Starting Lineup
Projected
PITCHERW-LERAWHIPK/9
Alec Gamboa logoLA.Gamboa, P1-01.161.0656.39
HITTERSAVGOBPSLGHR
Roman Anthony logo1R.Anthony, LF.235.328.3735
Mickey Gasper logo2M.Gasper, C.255.362.47310
Adley Rutschman logo3A.Rutschman, DH.251.331.4338
Wilyer Abreu logo4W.Abreu, RF.251.330.45124
Caleb Durbin logo5C.Durbin, 3B.250.335.38213
Nick Sogard logo6N.Sogard, 2B.258.342.3935
Jarren Duran logo7J.Duran, CF.208.265.36420
Andruw Monasterio logo8A.Monasterio, 1B.238.301.3806
Isiah Kiner-Falefa logo9I.Kiner-Falefa, SS.237.312.3082

Cubs vs. Red Sox Odds Comparison

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Cubs at Red Sox Team Totals

MatchupOverUnder
Cubs
88-71
N/A
N/A
Red Sox
85-74
N/A
N/A