Guardians vs Red Sox Odds: Moneyline, Over/Under, Props - September 22, 2026

Guardians at Red Sox

10:45 pm • CLEG

Cleveland Guardians

5-6

3 - 2

Boston Red Sox

0-2

pitcher		team	era	w-l
P.Tolle			3.03	9-6
P.Messick			2.56	12-9

MatchupOpenSpreadTotalMoneyline
Guardians 5-6	+1.5	-1.5+125	o6.5-105	+102
Red Sox 0-2	u6.5	-1.5+183	u6.5+105	-121

Tuesday 10:45 p.m.

September 22, 2026

Fenway ParkBoston

BOS -125

1.25u

P.Messick o5.5 Ks-135

0.68u

CLE +125 (Live)

CLE +117

3.51u

BOS -124

0.5u

Under 6+100

Wind In Good Home Pitcher (***) Overall: 269-162-12,62% (ROI:20%) Season:10-2-1,83% (ROI:54%) Chilly Park Unders (***) Overall: 437-254-33,63% (ROI:21%) Season:19-20-3,49% (ROI:-6%) Flatline Unders (***) Overall: 428-306-44,58% (ROI:12%) Season:13-12-1,52% (ROI:1%) #TSA

BOS -117

0.59u

On #Novig

D.Fry u0.5 Hits-120

0.25u

@DerekCarty ⭐️ https://podcasts.apple.com/us/podcast/payoff-pitch/id1615600022?i=1000791125197

BOS -125

0.5u

@cowhitchurch ⭐️⭐️ https://podcasts.apple.com/us/podcast/payoff-pitch/id1615600022?i=1000791125197

CLE +110

1.1u

Guardians vs Red Sox: Collin's ML Pick
Collin Whitchurch•
Sep 22, 2026 UTC
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MLB Public Betting

Red Sox are 3-2 in their last 5 games.
Red Sox are 2-3 in their last 5 games against the spread
Red Sox are 41-40 in their road games against the spread
The totals have gone OVER in 1 of Red Sox' last 5 games
The totals have gone OVER in 35 of Red Sox' 80 last games at home

Against the Spread (ATS) History

	overall	home	away	favorite	underdog
Red Sox	76-85	35-45	41-40	48-64	27-21
Guardians	79-83	36-45	43-38	43-55	36-24

Over/Under History

	overall	home o/u	away o/u	favorite o/u	underdog o/u
Red Sox	71-86-4	35-42-3	36-44-1	51-58-3	20-27-1
Guardians	77-85	42-39	35-46	48-50	27-33

Straight-Up (ML) History

	overall	home	away	favorite	underdog
Red Sox	87-75	41-39	46-35	61-51	25-23
Guardians	85-77	41-40	44-37	55-43	30-30

date	opponent	score	spread	over/under	moneyline
Sep 20th	@TB	L 1-5	+1.5 L	U 7.5	TB +126
Sep 19th	@TB	L 1-2	+1.5 W	U 7.5	TB +125
Sep 18th	@TB	W 4-2	+1.5 W	U 7.5	BOS +114
Sep 18th	@TEX	W 4-3	-1.5 L	U 8	BOS -130
Sep 17th	@TEX	L 3-7	-1.5 L	O 8	TEX -112

Tanner Houck
SP
Houck is out with arm
Out
Triston Casas
1B
Casas is out with knee
Out
Kutter Crawford
SP
Crawford is out with wrist
Out

See more MLB Injuries

PITCHER	PC	IP	K	ER
LP.Messick, P	96	5	5	1
LT.Herrin, P	14	0.2	0	0
RC.Yoho, P	13	0.1	1	0
LE.Sabrowski, P	19	1	3	0
RH.Gaddis, P	18	1	2	1
RC.Smith, P	16	1	1	0

HITTERS	H-AB	R	RBI
1S.Kwan, CF	1-4	0	0
1S.Kwan, LF	1-4	0	0
2J.Ramirez, 3B	1-5	0	0
3C.DeLauter, RF	2-4	1	0
4J.Adell, DH	1-4	0	0
5A.Martinez, LF	3-4	1	0
5N.Lowe, 1B	0-0	0	1
6D.Fry, 1B	1-3	1	1
6P.Halpin, PR	1-1	0	0
6P.Halpin, CF	1-1	0	0
7T.Bazzana, 2B	1-4	0	0
7A.Genao, 2B	0-1	0	0
8A.Hedges, C	0-3	0	0
9B.Rocchio, SS	1-5	0	0

PITCHER	PC	IP	K	ER
LP.Tolle, P	91	5.2	5	2
LA.Gamboa, P	29	1.1	1	0
LJ.Moran, P	16	1	3	0
LE.Miller, P	22	1	0	1

HITTERS	H-AB	R	HR	RBI
1R.Anthony, LF	0-5	0	0	0
2N.Sogard, 1B	2-5	0	0	0
3J.Jones, DH	0-3	0	0	0
3M.Gasper, PH	1-1	1	1	1
3M.Gasper, DH	1-1	1	1	1
4W.Abreu, RF	1-4	0	0	0
5A.Rutschman, C	3-4	1	0	0
6C.Durbin, 3B	0-2	0	0	0
7A.Monasterio, 2B	0-3	0	0	1
8I.Kiner-Falefa, SS	0-3	0	0	0
9N.Eaton, CF	1-3	0	0	0
9J.Duran, PH	0-0	0	0	0