Guardians vs. Red Sox Odds & Betting Predictions - September 23, 2026

Guardians at Red Sox

11:10 pm • ESPN
0 - 1
Starting Pitchers
pitcherteameraw-l
Sonny Gray logoS.GrayBoston Red Sox logo2.7218-5
Foster Griffin logoF.GriffinCleveland Guardians logo5.193-3

Guardians at Red Sox Odds

Spread, Total, Moneyline

MatchupOpenSpreadTotalMoneyline
Guardians
5-6
+1.5
+1.5-199
o6.5-114
+119
Red Sox
0-2
u7.5
-1.5+163
u6.5-104
-142
location pinWednesday 11:10 p.m.
September 23, 2026
Fenway ParkBoston
Guardians vs. Red Sox Expert Picks
Mike McNamara
Mike McNamara
Last 30d: 80-57-1 (+10.4u)
BOS -136
0.2u
Doug Ziefel
Doug Ziefel
Last 30d: 411-345-10 (+42.8u)
F.Griffin o4.5 Ks+102
0.5u
J.Jones u0.5 Hits+120
0.42u
The Degenerates
The Degenerates
Last 30d: 74-69-1 (-2.1u)
Under 3.5 (F5)-110
1u
Brian Bitler
Brian Bitler
Last 30d: 70-80-1 (-27.7u)
CLE +120
3u
Austin Pendergrass
Austin Pendergrass
Last 30d: 82-62-0 (+5.5u)
Under 0.5 (1st Inn)-146
0.34u
Topper
Topper
Last 30d: 115-105-2 (-22.7u)
Under 6.5+100
1u
Wind In Good Home Pitcher (***) Overall: 268-157-12,63% (ROI:21%) Season:11-2-1,85% (ROI:57%) Late szn Non Division Under Streak Overall: 125-54-6,70% (ROI:34%) Season:0-0-0, 0% (ROI: 0%) #TSA
Adam Kaufman
Adam Kaufman
Last 30d: 334-306-16 (-15.2u)
CLE +114
1u
Derek Carty
Derek Carty
Last 30d: 25-19-0 (+14.2u)
J.Jones u0.5 Hits+130
1u
There is a value opportunity on Jahmai Jones's hits prop. THE BAT X is projecting him to record 0.64 hits, while oddsmakers are implying 0.80. The model believes there is a 53% chance he records fewer than 1 hit, so there is value on the under at +130. This play is good down to at least +109. Love THE BAT X? Get all of Carty's sports betting projections at EV Analytics https://evanalytics.com/subscribe/mlb?ref=zdlkmgz

Guardians vs. Red Sox Previews & Analysis

  • Guardians vs Red Sox: Ride the Fenway Wind Edge article feature image

    Guardians vs Red Sox: Ride the Fenway Wind Edge

    Action Network Staff•
    Sep 23, 2026 UTC
See more MLB Coverage Right Arrow

Prop Odds Comparison

Right Arrow
Right Arrow

Loading props…

Line Movement Tracker

Right Arrow
Right Arrow

Guardians vs. Red Sox Public Betting Percentages

Away Logo

Guardians

Public

33%

Bets%

67%

Money%

Matchup History

Against the Spread (ATS) History

overallhomeawayfavoriteunderdog
Red Sox
76-8535-4541-4048-6427-21
Guardians
79-8336-4543-3843-5536-24

Over/Under History

overallhome o/uaway o/ufavorite o/uunderdog o/u
Red Sox
71-86-435-42-336-44-151-58-320-27-1
Guardians
77-8542-3935-4648-5027-33

Straight-Up (ML) History

overallhomeawayfavoriteunderdog
Red Sox
87-7541-3946-3561-5125-23
Guardians
85-7741-4044-3755-4330-30

Last 5 Matchups

dateopponentscorespreadover/undermoneyline
Sep 22ndCLEL 2-3-1.5 LU 6.5CLE -121
Sep 20th@TBL 1-5+1.5 LU 7.5TB +126
Sep 19th@TBL 1-2+1.5 WU 7.5TB +125
Sep 18th@TBW 4-2+1.5 WU 7.5BOS +114
Sep 18th@TEXW 4-3-1.5 LU 8BOS -130

Red Sox vs. Guardians Injury Updates

Red Sox Injuries

  • Tanner Houck
    SP

    Houck is out with arm

    Out

  • Triston Casas
    1B

    Casas is out with knee

    Out

  • Kutter Crawford
    SP

    Crawford is out with wrist

    Out

Guardians Injuries

    Guardians vs. Red Sox Box Score
    Guardians Player Stats
    Projected
    PITCHERPCIPKER
    Foster Griffin logoLF.Griffin, P83671
    Tim Herrin logoLT.Herrin, P21130
    Matt Festa logoRM.Festa, P140.200
    Shawn Armstrong logoRS.Armstrong, P10.100
    HITTERSH-ABRHRRBI
    Steven Kwan logo1S.Kwan, LF2-4000
    Jose Ramirez logo2J.Ramirez, 3B0-3000
    Chase DeLauter logo3C.DeLauter, DH0-4000
    Jo Adell logo4J.Adell, RF0-3000
    Travis Bazzana logo5T.Bazzana, 2B0-2000
    Angel Martinez logo5A.Martinez, PH0-1000
    Nathaniel Lowe logo6N.Lowe, 1B0-3000
    Angel Genao logo6A.Genao, PH0-1000
    Patrick Bailey logo7P.Bailey, C1-3000
    Petey Halpin logo8P.Halpin, CF1-3000
    Brayan Rocchio logo9B.Rocchio, SS1-3000
    Red Sox Player Stats
    Projected
    PITCHERPCIPKER
    Sonny Gray logoRS.Gray, P77630
    Tayron Guerrero logoRT.Guerrero, P22130
    Garrett Whitlock logoRG.Whitlock, P20100
    Aroldis Chapman logoLA.Chapman, P12130
    HITTERSH-ABRHRRBI
    Roman Anthony logo1R.Anthony, LF1-4000
    Nick Sogard logo2N.Sogard, 1B2-4000
    Jahmai Jones logo3J.Jones, DH2-4000
    Wilyer Abreu logo4W.Abreu, RF2-4000
    Adley Rutschman logo5A.Rutschman, C1-4000
    Ceddanne Rafaela logo6C.Rafaela, CF1-1000
    Jarren Duran logo6J.Duran, CF2-3100
    Caleb Durbin logo7C.Durbin, 3B0-4000
    Trevor Story logo8T.Story, SS0-4000
    Andruw Monasterio logo9A.Monasterio, 2B1-3001
    Mickey Gasper logo9M.Gasper, PH0-1000
    Isiah Kiner-Falefa logo9I.Kiner-Falefa, 2B0-0000

    Guardians vs. Red Sox Odds Comparison

    Right Arrow

    Could not load odds

    Guardians at Red Sox Team Totals

    MatchupOverUnder
    Guardians
    5-6
    N/A
    N/A
    Red Sox
    0-2
    N/A
    N/A