White Sox vs. Guardians Odds & Betting Predictions - September 13, 2025

White Sox at Guardians

10:10 pm • CHSN

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Chicago White Sox

@

Cleveland Guardians

pitcher		team	era	w-l
P.Messick			1.93	2-0
D.Martin			4.03	6-9

MatchupOpenSpreadTotalMoneyline
White Sox 57-91	+1.5	+1.5-155	o7.5-120	+141
Guardians 76-71	u8	-1.5+128	u7.5-102	-167

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Saturday 10:10 p.m.

September 13, 2025

Progressive FieldCleveland

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72°Fahrenheit

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Saturday's MLB Best Bets
Action Network Staff•
Sep 13, 2025 UTC

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MLB Public Betting

Guardians are 4-1 in their last 5 games.
Guardians are 4-1 in their last 5 games against the spread
Guardians are 41-33 in their road games against the spread
The totals have gone OVER in 1 of Guardians' last 5 games
The totals have gone OVER in 34 of Guardians' 73 last games at home

Against the Spread (ATS) History

	overall	home	away	favorite	underdog
Guardians	77-70	36-37	41-33	30-30	46-38
White Sox	87-61	44-31	43-30	0-2	86-59

Over/Under History

	overall	home o/u	away o/u	favorite o/u	underdog o/u
Guardians	64-77-6	34-36-3	30-41-3	31-28-1	32-47-5
White Sox	70-71-7	40-30-5	30-41-2	0-2	69-69-7

Straight-Up (ML) History

	overall	home	away	favorite	underdog
Guardians	76-71	39-34	37-37	38-22	38-46
White Sox	57-91	32-43	25-48	1-1	55-90

date	opponent	score	spread	over/under	moneyline
Sep 12th	CWS	W 4-0	-1.5 W	U 7.5	CLE -142
Sep 11th	KC	W 3-2	-	-	CLE -144
Sep 10th	KC	L 3-4	+1.5 W	U 8	KC -110
Sep 9th	KC	W 2-0	+1.5 W	U 7.5	CLE -110
Sep 8th	KC	W 10-2	+1.5 W	O 7.5	CLE -115

Ben Lively
SP
Lively is out with elbow
Out
John Means
SP
Means is out with elbow
Out

Ky Bush
SP
Bush is out with elbow
Out
Drew Thorpe
SP
Thorpe is out with elbow
Out

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PITCHER		W-L	ERA	WHIP	K/9
RD.Martin, P		6-9	4.03	1.280	6.51

HITTERS	AVG	OBP	SLG	HR
1C.Meidroth, 2B	.269	.348	.338	4
2C.Mead, 1B	.226	.318	.339	3
3E.Quero, DH	.279	.343	.379	5
4C.Montgomery, SS	.224	.292	.527	18
5M.Vargas, 3B	.231	.314	.399	14
6M.Taylor, CF	.201	.258	.369	8
7A.Benintendi, LF	.246	.309	.435	19
8K.Lee, C	.257	.333	.429	1
9W.Robertson, RF	.100	.250	.100	0

PITCHER		W-L	ERA	WHIP	K/9
LP.Messick, P		2-0	1.93	1.329	6.94

HITTERS	AVG	OBP	SLG	HR
1S.Kwan, LF	.275	.334	.378	10
2G.Valera, DH	.176	.263	.176	0
3J.Ramirez, 3B	.283	.356	.504	28
4K.Manzardo, 1B	.239	.323	.472	26
5N.Jones, CF	.214	.300	.308	5
6D.Schneemann, 2B	.217	.297	.370	11
7B.Rocchio, SS	.236	.294	.338	4
8B.Naylor, C	.181	.274	.346	11
9C.Kayfus, RF	.200	.267	.400	3

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MatchupOverUnder
White Sox 57-91	N/A	N/A
Guardians 76-71	N/A	N/A