MLB Saturday Betting Odds, Picks, Predictions: The Big Edges on Reds vs. Blue Jays, Twins vs. Royals (May 21)

It's a glorious day to bet baseball, with 16 MLB games on tap Saturday. However, two of those — Twins vs. Royals and Reds vs. Blue Jays — demand a little bit more attention than the others.

The American League tilt and interleague clash are shaping up to create a pair of big-time betting edges in our databases – one over/under, and another side.

We've tracked an avalanche of money rolling in on both plays, plus we'll dive into a top-rated system that applies for the moneyline play.

Here's where the value's at this weekend.

Reds vs. Blue Jays Pick

3:07 p.m. ET

One sharp play for Saturday is Toronto, which hosts Cincinnati in the afternoon window.

The Blue Jays fit our Average AL Teams vs. NL (PRO) system, which has the best win rate (63%) among our MLB models.

It banks on AL home teams in interleague play. Here, we're fading the 11-27 Reds, who have lost $100 bettors more than $1300 so far this season.

We'll back Alek Manoah and the Jays, along with the 98% of the public that's submitted a ticket on Toronto.

PRO Pick: Blue Jays -250

Twins vs. Royals Pick

7:05 p.m. ET

Our PRO Report strongly endorses a play on the Twins-Royals over the total.

Despite 54% of the tickets on the over, we've logged a hefty 86% of the money rooting for runs; in turn, our Big Money PRO tool lit up this morning, indicating where sharp money's headed.

Our numbers also disagree with the current over/under, which is at a consensus price of 7.5 in the market.

We make the total 8.17, good for a 5.5% betting edge and B-rated play.

PRO Pick: Over 7.5