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Syracuse vs. Clemson Odds & Betting Predictions - September 20, 2025

Syracuse at Clemson

4:00 pm • ESPN

Syracuse Orange

0-0
34
34 - 21

Clemson Tigers

0-0
21

Syracuse at Clemson Odds

Spread, Total, Moneyline

MatchupOpenSpreadTotalMoneyline
Syracuse
0-0
+16.5
+17.5-108
o53.5-112
+600
Clemson
0-0
u55.5
-17.5-112
u53.5-110
-900
location pinSaturday 4:00 p.m.
September 20, 2025
Memorial Stadium (Clemson, SC)Clemson
Syracuse vs. Clemson Expert Picks
Collin Wilson
Collin Wilson
Last 30d: 0-0-0 (+0.0u)
CLEM +7.5 (Live)-115
1.15u
Capper Central
Capper Central
Last 30d: 3-0-1 (+3.8u)
CLEM -16.5-118
2.36u
Wags Wins
Wags Wins
Last 30d: 250-273-4 (-8.4u)
CLEM -16.5-118
1.25u
Brian Bitler
Brian Bitler
Last 30d: 92-83-0 (+35.7u)
CLEM -17-110
3u
Jeremiah Rose
Jeremiah Rose
Last 30d: 1-7-0 (-2.1u)
CLEM -16.5-115
0.25u
Boyd / FanDuel
💰🦡 Jake
💰🦡 Jake
Last 30d: 66-72-2 (+1.7u)
CLEM -9.5 (1H)-115
1.15u
Dan Gaspar
Dan Gaspar
Last 30d: 24-23-0 (-1.4u)
T.Moore o3.5 Recs+120
1.2u
New Owner
New Owner
Last 30d: 62-62-0 (+15.7u)
CLEM -17+100
1u
Doug Ziefel
Doug Ziefel
Last 30d: 257-326-18 (-25.0u)
Under 56.5-110
0.5u

Syracuse vs. Clemson Previews & Analysis

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    5 Star QBs, 5 Player Prop Picks

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  • Syracuse vs. Clemson: Should You Target Total? article feature image

    Syracuse vs. Clemson: Should You Target Total?

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  • Our NCAAF Best Bets for Saturday's Noon Games article feature image

    Our NCAAF Best Bets for Saturday's Noon Games

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    Sep 20, 2025 UTC
  • Your Week 4 NCAAF Betting Cheat Sheet article feature image

    Your Week 4 NCAAF Betting Cheat Sheet

    Pete Ruden•
    Sep 20, 2025 UTC
See more NCAAF Coverage Right Arrow

Prop Odds Comparison

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No props found

Line Movement Tracker

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Syracuse vs. Clemson Public Betting Percentages

Away Logo

Syracuse

Public

Home Logo

Clemson

62%

Bets%

38%

Money%

NCAAF Public Betting Right Arrow

Matchup History

Against the Spread (ATS) History

overallhomeawayfavoriteunderdog
Clemson		N/AN/AN/AN/AN/A
Syracuse		N/AN/AN/AN/AN/A

Over/Under History

overallhome o/uaway o/ufavorite o/uunderdog o/u
Clemson		N/AN/AN/AN/AN/A
Syracuse		N/AN/AN/AN/AN/A

Straight-Up (ML) History

overallhomeawayfavoriteunderdog
Clemson		N/AN/AN/AN/AN/A
Syracuse		N/AN/AN/AN/AN/A

Last 5 Matchups

dateopponentscorespreadover/undermoneyline
Sep 13th@GTL 21-24-3 LU 50.5GT -145
Sep 6thTROYW 27-16-30.5 LU 51.5CLEM -11946
Aug 30thLSUL 10-17-5 LU 55.5LSU -205
Dec 21st@TEXL 24-38+13.5 LO 49.5TEX +470
Dec 8th@SMUW 34-31+2.5 WO 56.5CLEM +111
Team Stats

Total

433
Total Yards
503
77
Total Plays
83
5.623376623376624
Yards Per Play
6.0602409638554215

Passing

278
YDS
363
21/39
Comps/Atts
37/61
7.128205128205129
YPA
5.950819672131147
3/0
TDs/INTs
3/1
3/11
Sacks/Yards
1/1

Rushing

155
Rush Yards
140
38
Attempts
22
4.078947368421052
YPC
6.363636363636363
1
TDs
0

Turnovers

0
Fumbles Lost
1
0
Interceptions
1

Efficiency

4/4 100%
Redzone
2/2 100%
3/15 0%
3rd Down
3/13 0%
2/2 0%
4th Down
1/5 0%

First Downs

24
Total
29
13
Pass
19
8
Rush
7
3
Penalty
3

Misc

7/52
Penalties/Yards
8/75

Syracuse vs. Clemson Odds Comparison

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Syracuse at Clemson Team Totals

MatchupOverUnder
Syracuse
0-0
N/A
N/A
Clemson
0-0
N/A
N/A