College Football Betting Predictions, Picks: Maryland-Ohio State, Notre Dame-Virginia Tech Lead Sharpest Early Week 6 Bets

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Rich Graessle/Icon Sportswire via Getty Images. Pictured: Ohio State Buckeyes cornerback Denzel Burke (29) and safety Bryson Shaw (17) tackle Rutgers Scarlet Knights running back Isaih Pacheco.

PJ Walsh

Updated:

Oct 09, 2021, 08:43 AM EDT

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Saturday's Maryland vs. Ohio State and Notre Dame vs. Virginia Tech games are among the sharpest college football betting picks for Saturday's Week 6 slate.
Professional bettors are also already keying in on Saturday's Wyoming vs. Air Force and South Alabama vs. Texas State college football Week 6 matchups.
Using our PRO betting tools, we detail sharp betting predictions and picks for each of these four games.

With an interesting Monday Night Football matchup between the Las Vegas Raiders and Los Angeles Chargers, along with the New York Yankees taking on the Boston Red Sox in a winner-take-all Wild Card matchup on Tuesday, college football's Week 6 slate is more under-the-radar than usual.

Well, it certainly is for recreational college football bettors, but for sharps, not so much.

Professionals are already taking whacks at a handful of Saturday's Week 6 matchups, including Maryland vs. Ohio State and Notre Dame vs. Virginia Tech.

Let's take a detailed look at four college football Week 6 games that wiseguys are already hammering.