The Louisville Cardinals take on the James Madison Dukes in Friday night college football action. The game on Sept. 5 kicks off at 7 p.m. ET and will be broadcast on ESPN2.
Louisville enters as a -15.5 favorite on the spread (-630 on the moneyline), while JMU comes in as a +15.5 underdog on the spread (+450 on the moneyline), The over/under, meanwhile, sits at 55 total points.
Both teams enter this game at 1-0 with wins over FCS foes. The Cardinals destroyed in-state foe Eastern Kentucky, 51-17, while the Dukes toppled Weber State by a score of 45-10.
I put together a two-leg same-game parlay for Friday's matchup, featuring a play on the over/under and a player prop milestone.
Let's take a look at the Louisville vs. JMU oddsand my college football picks for this NCAAF Week 2 clash on Friday night.
Louisville vs. JMU Odds
JMU Odds | ||
---|---|---|
Spread | Total | Moneyline |
+15.5 -110 | 55.5 -110o / -110u | +450 |
Louisville Odds | ||
---|---|---|
Spread | Total | Moneyline |
-15.5 -110 | 55.5 -110o / -110u | -630 |
Louisville vs. JMU Picks, Parlay
- Over 55.5
- Alonza Barnett III 160+ Passing Yards
Parlay Payout: +130 (via DraftKings)


Over/Under Pick: Over 55.5
The Dukes and Cardinals will clash under the Friday night lights in Louisville, Kentucky, on Sept. 5.
James Madison enters the season as the betting favorite to win the Sun Belt, and for good reason. JMU opened the season with a wire-to-wire victory over Weber State and will now have its first true test against a Power 4 opponent.
Louisville, meanwhile, opened its season with a comfortable 51-17 win over Eastern Kentucky.
I expect both offenses to stay sharp in this matchup tonight.
James Madison signal-caller Alonza Barnett is a talented dual-threat quarterback who will have success against this young Cardinals defense.
On the other side, Louisville quarterback Miller Moss impressed in Week 1, and I expect the Cardinals to find a way to do whatever they want on the offensive side of the ball.

JMU Player Prop Pick: Alonza Barnett III 160+ Pass Yards
Barnett, the Whisett, North Carolina, native, threw for just 130 yards in the season opener due to the Dukes' blowout win.
Tonight, they'll need his arm to keep them in the game.
As mentioned, I believe the Cardinals will move the ball consistently tonight, forcing JMU to keep pace. The negative game script will bode well for the junior to cash this prop tonight.
Needing to keep pace with Moss and Louisville head coach Jeff Brohm's offense, Barnett should have plenty of opportunities to put the ball in the air tonight.
The payout of this parlay comes in at +130, giving us a nice boost for what should turn into a high-scoring ACC/Sun Belt matchup on Friday night.
Louisville vs. JMU Same-Game Parlay, Predictions
- Over 55.5
- Alonza Barnett III 160+ Passing Yards
Parlay Payout: +130 (via DraftKings)