No. 21 USC puts its undefeated record on the line at No. 23 Illinois on Saturday in Champaign.
The Trojans have dispatched two power-conference teams this season in Purdue and Michigan State, beating both by double digits. Meanwhile, the Illini's lone loss came in an embarrassing 63-10 defeat to No. 19 Indiana last week.
Below, I have an Illinois vs USC parlay for college football Week 5.


Illinois vs USC Picks
- Illinois +6.5
- Luke Altmyer 200+ Passing Yards
Parlay Payout: +162 (via bet365)
Illinois vs USC Odds
Illinois Odds | ||
---|---|---|
Spread | Total | Moneyline |
+6.5 -110 | 59.5 -110o / -110u | +195 |
USC Odds | ||
---|---|---|
Spread | Total | Moneyline |
-6.5 -110 | 59.5 -110o / -110u | -240 |
- Illinois vs USC point spread: USC -6.5
- Illinois vs USC over/under: 59.5 points
- Illinois vs USC moneyline: Illinois +195, USC -240

Illinois +6.5
Illinois will look to bounce back after a disastrous Week 3 showing against Indiana, as Brett Bielema’s team was thoroughly outplayed in a 63-10 loss under the lights in Bloomington.
Despite that setback, this feels like an ideal bounce-back spot for the Illini on their home field.
USC finds itself in a difficult position, traveling across the country for a 9 a.m. ET kickoff — a situational spot that historically hasn’t treated the Trojans well.
Since 2013, the Trojans are just 1-13 ATS and 1-12 outright in games played in Central or Eastern Time Zones.
Facing a hungry and experienced Illinois team, this is a daunting challenge for USC.

Luke Altmyer 200+ Passing Yards
I expect Illinois to find success against this USC secondary, which has looked vulnerable in recent weeks.
In their last game, the Trojans gave up 225 passing yards to a below-average Michigan State offense, and the week before, they surrendered 305 yards through the air against Purdue.
With this matchup likely to develop into a close, back-and-forth battle, the game script should work in Luke Altmyer’s favor, forcing him to throw often, which gives this prop plenty of upside.