Here are the best NFL prop bets today for Week 5, live from the Polymarket board. Get the Polymarket promo code ACTION for a new $25 trading bonus and trade Sunday's full NFL slate.
A 13-game Sunday slate headlines NFL Week 5, and with favorites and longshots spread across every window of the day, this roundup of the best NFL prop bets today pulls the top picks straight from the live Polymarket NFL odds board.
- Houston and Jacksonville sit at the top of the board as the week's biggest favorites, while Tennessee and Philadelphia anchor the other end as the deepest moneyline longshots.
- The slate runs from the 1:30 PM ET London window (Eagles-Jaguars) through the late afternoon window (Lions-Cardinals, 49ers-Seahawks), with Ravens-Falcons closing out Sunday Night Football.
Here is our full picks table before we break down every pick and the complete moneyline, spread, and total board for the week. You can trade on these picks on one of the best prediction market apps in Polymarket today.
| 🏈 NFL Prediction | 🏷️ Position | Price | 🤑 Profit on $100 | 📈 Trade It Now |
|---|---|---|---|
| Houston Texans to Win (vs. Titans) | Yes | 78¢ | $28.21 | Trade it on Polymarket! |
| Jacksonville Jaguars to Win (vs. Eagles) | Yes | 77¢ | $29.87 | Trade it on Polymarket! |
| Cincinnati Bengals -6.5 (vs. Dolphins) | Yes | 52¢ | $92.31 | Trade it on Polymarket! |
| Detroit Lions -5.5 (vs. Cardinals) | Yes | 51¢ | $96.08 | Trade it on Polymarket! |
| San Francisco 49ers +3.5 (vs. Seahawks) | Yes | 54¢ | $85.19 | Trade it on Polymarket! |
| Under 38.5 (Texans vs. Titans) | Yes | 54¢ | $85.19 | Trade it on Polymarket! |
| Philadelphia Eagles to Win (vs. Jaguars) | Yes | 24¢ | $316.67 | Trade it on Polymarket! |
| Tennessee Titans to Win (vs. Texans) | Yes | 23¢ | $334.78 | Trade it on Polymarket! |
Best NFL Prop Bets Today for Week 5
Every pick below is a real trade we'd make after redeeming the Polymarket promo code ACTION, ranked from the safest number down to the long shots.
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Best Moneyline Pick Today – Houston Texans to Win
| 🏈 NFL Prediction | 🏷️ Position | Price | 🤑 Profit on $100 | 📈 Trade It |
|---|---|---|---|
| Houston Texans to Win | Yes | 78¢ | $28.21 | Trade it now on Polymarket! |
Houston and Tennessee both enter winless, but the gap between them shows up clearly here: the Texans have stayed competitive against a tougher slate, while the Titans have simply been overmatched. At 78 cents, a $100 buy is roughly 128 shares.
- If Houston wins: profit of $28.21.
- If not: the $100 stake is a total loss.
It's the safest number on the board this week, and the gap in schedule strength backs it up.
Best Spread Pick Today – Detroit Lions -5.5
| 🏈 NFL Prediction | 🏷️ Position | Price | 🤑 Profit on $100 | 📈 Trade It |
|---|---|---|---|
| Detroit Lions -5.5 | Yes | 51¢ | $96.08 | Trade it now on Polymarket! |
Detroit has been one of the league's steadier teams at home this season, and the roster gap over Arizona is real even if the number itself sits close to even money. A $100 buy at 51 cents is roughly 196 shares.
- If Detroit wins by 6 or more: profit of $96.08.
- If not: the $100 stake is a total loss.
Best Total Pick Today – Under 38.5 (Texans vs. Titans)
| 🏈 NFL Prediction | 🏷️ Position | Price | 🤑 Profit on $100 | 📈 Trade It |
|---|---|---|---|
| Under 38.5 | Yes | 54¢ | $85.19 | Trade it now on Polymarket! |
Two winless offenses meeting head-on is exactly the kind of matchup that tends to bog down into a field-position battle rather than a shootout. A $100 buy at 54 cents is roughly 185 shares.
- If the combined score stays under 38.5: profit of $85.19.
- If not: the $100 stake is a total loss.
Best Longshot Pick Today – Tennessee Titans to Win
| 🏈 NFL Prediction | 🏷️ Position | Price | 🤑 Profit on $100 | 📈 Trade It |
|---|---|---|---|
| Tennessee Titans to Win | Yes | 23¢ | $334.78 | Trade it now on Polymarket! |
Nothing about Tennessee's season points to an upset here, but in a game this low-scoring, one well-timed defensive or special-teams score can flip the outcome fast. At 23 cents, a $100 buy is roughly 435 shares.
- If Tennessee wins: profit of $334.78.
- If not: the $100 stake is a total loss.
It's the deepest moneyline longshot of the week.
Full NFL Week 5 Board: Moneyline, Spread & Total
| Game | Moneyline | Spread | Total |
|---|---|---|---|
| Eagles vs. Jaguars (1:30 PM) | PHI 24¢ / JAX 77¢ | PHI +7.5 50¢ / JAX -7.5 51¢ | O42.5 48¢ / U42.5 53¢ |
| Bears vs. Packers (5:00 PM) | CHI 53¢ / GB 48¢ | CHI -1.5 49¢ / GB +1.5 52¢ | O46.5 48¢ / U46.5 53¢ |
| Giants vs. Commanders (5:00 PM) | NYG 37¢ / WAS 64¢ | NYG +3.5 49¢ / WAS -3.5 52¢ | O41.5 51¢ / U41.5 50¢ |
| Raiders vs. Patriots (5:00 PM) | LV 37¢ / NE 64¢ | LV +3.5 49¢ / NE -3.5 52¢ | O45.5 49¢ / U45.5 52¢ |
| Browns vs. Jets (5:00 PM) | CLE 45¢ / NYJ 56¢ | CLE +2.5 50¢ / NYJ -2.5 51¢ | O40.5 47¢ / U40.5 54¢ |
| Vikings vs. Saints (5:00 PM) | MIN 57¢ / NO 44¢ | MIN -2.5 50¢ / NO +2.5 51¢ | O42.5 50¢ / U42.5 51¢ |
| Texans vs. Titans (5:00 PM) | HOU 78¢ / TEN 23¢ | HOU -7.5 50¢ / TEN +7.5 51¢ | O38.5 47¢ / U38.5 54¢ |
| Colts vs. Steelers (5:00 PM) | IND 43¢ / PIT 58¢ | IND +2.5 48¢ / PIT -2.5 53¢ | O44.5 47¢ / U44.5 54¢ |
| Bengals vs. Dolphins (5:00 PM) | CIN 75¢ / MIA 26¢ | CIN -6.5 52¢ / MIA +6.5 49¢ | O42.5 55¢ / U42.5 46¢ |
| Broncos vs. Chargers (8:05 PM) | DEN 63¢ / LAC 38¢ | DEN -3.5 49¢ / LAC +3.5 52¢ | O42.5 48¢ / U42.5 53¢ |
| Lions vs. Cardinals (8:25 PM) | DET 70¢ / ARI 31¢ | DET -5.5 51¢ / ARI +5.5 50¢ | O54.5 50¢ / U54.5 51¢ |
| 49ers vs. Seahawks (8:25 PM) | SF 39¢ / SEA 62¢ | SF +3.5 54¢ / SEA -3.5 47¢ | O46.5 49¢ / U46.5 52¢ |
| Ravens vs. Falcons (SNF, 8:20 PM) | BAL 39¢ / ATL 62¢ | BAL +3.5 53¢ / ATL -3.5 48¢ | O43.5 52¢ / U43.5 49¢ |
What's Moving the Market
Prediction markets and prices move for several reasons this week, and the gap at the top of the board tells most of the story. Houston and Jacksonville are the two biggest favorites on the board despite Houston sitting winless — a sign the market still trusts Houston's underlying talent over a brutal early schedule more than it trusts the record itself.
On the other end, winless Tennessee sits as the week's longest shot, while Philadelphia finds itself in the unusual position of being an underdog on the road in London — the clearest reminder that Jacksonville's number as the week's second-biggest favorite at home isn't one to overlook.
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Final Thoughts: Best NFL Prop Bets Today
Houston and Jacksonville headline the favorites this week, while Tennessee and Philadelphia offer the deepest longshot value on the moneyline — and the two sit at opposite ends of the board for very different reasons. That wraps our full best NFL prop bets today roundup for Week 5 on the Polymarket board.
Best NFL Prop Bets Today FAQs
What is the Polymarket promo code for NFL Week 5?
The current Polymarket promo code is ACTION. New users who sign up with it can deposit $10 and get a new $25 trading bonus.
Who are the biggest favorites in NFL Week 5?
Houston (78¢) and Jacksonville (77¢) are the two biggest moneyline favorites on the Polymarket board this week.
Who are the biggest underdogs in NFL Week 5?
Tennessee (23¢) and Philadelphia (24¢) are the week's longest moneyline shots.
