The Seattle Seahawks (6-2) host the Arizona Cardinals (3-5) in NFL Week 10 on Sunday, Nov. 9. Kickoff is set for 4:05 p.m. ET from Lumen Field in Seattle, Was. The game will broadcast on CBS.
The Seahawks are 6.5-point favorites over the Cardinals on the spread (Seahawks -6.5); the game total is 45 points. Seattle is a -310 moneyline favorite and Arizona is +255 to pull off the upset.
Let's get into my Week 10 preview for this NFC West showdown, which includes my Cardinals vs Seahawks prediction.
Cardinals vs Seahawks Prediction
- Cardinals vs Seahawks pick: Cardinals +6.5 (-110)
My Seahawks vs Cardinals best bet is on Arizona to cover the spread. Find the best odds by checking our live NFL odds page.
Cardinals vs Seahawks Odds
| Cardinals Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+6.5 -110 | 45 -110o / -110u | +255 |
| Seahawks Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-6.5 -110 | 45 -110o / -110u | -310 |
Cardinals vs Seahawks NFL Week 10 Preview
The Cardinals are the most underrated team in the NFL right now, even after what they did in Dallas on Monday, when they completely shut down the Cowboys offense, which usually goes off at home.
There are a few reasons why Arizona is so formidable than its record would suggest.
First, the Cardinals offense is simply better with Jacoby Brissett at quarterback instead of Kyler Murray, who was placed on injured reserve with a foot injury.
Since Brissett took over in Week 6, Arizona ranks 11th in EPA per play, ninth in success rate, 11th in rush EPA and 12th in dropback EPA. From Weeks 1-5 (with Murray under center), they were worse in all those stats — 23rd in success rate, 20th in rush EPA. The offense is just a much smoother operation now.
One of the bigger developments for the offense with Brissett is that Marvin Harrison Jr. has looked good and fully involved.
Brissett has the lowest turnover-worthy play rate in the league and doesn’t take bad sacks, which is what's killed Murray against Seattle in the past.
The Seahawks have completely dominated the Cardinals under head coach Mike Macdonald because they’ve owned Murray. He can’t do anything against them.
Over the past three games across two seasons, Murray's averaged about six yards per attempt with five interceptions and 13 sacks.
Arizona has changed some of its offense — more play-action, better rhythm — and Brissett just has stronger command of it right now. There’s a reason they told Murray to go away, and I don’t think it has anything to do with his injury.
The Cardinals defense is one of the most underappreciated units in the league.
In the last matchup between these teams in September, they lost 23–20 in typical Cardinals fashion, but they also held Seattle’s offense in check as well as anyone has so far this season.
Jaxon Smith-Njigba had basically no catches through three quarters, and that was with the Cardinals missing both Will Johnson and Garrett Williams — two key corners.
Cardinals vs Seahawks Prediction, Betting Analysis
The Seahawks are top-five team in my power rankings, and I’m a believer in them long-term.
But they might be without defensive tackle Ernest Jones today, and that’s a big loss, especially against the run. They don’t have great depth there.
Sam Darnold has been arguably the best quarterback in the NFL this year. He’s been unbelievable — especially against the blitz, in play-action, and with explosive passes.
The thing is, Arizona is built to defend that. The Cardinals rarely blitz, they’re very good against play-action plays, and they’re elite at preventing explosive plays.
Arizona will keep everything in front of them and force Seattle to work down the field.
The Seahawks don't run the ball efficiently, but they do it because it sets up all the play-action and deep shots. Jaxon Smith-Njigba has arguably been the best receiver in the NFL, but Arizona’s defense won’t bite on the fakes.
The Cardinals can defend the run without bringing safeties down, without compromising the back end. They’re set up to actually contain this Seattle offense.
We’re at the very peak of Seattle’s market value right now — and Arizona is still undervalued. The Cardinals have lost three games at the buzzer and haven’t lost by more than four points all year.
Two of those were with Jacoby Brissett — at the Colts and against the Packers — so it’s not like they haven’t played real teams. This Arizona group competes in every game.
Under head coach Mike Macdonald, Seattle has gone on the road and destroyed teams, but it hasn't been great against the number at home.
In a divisional game, home-field advantage doesn’t mean as much. I like Arizona to hold this explosive Seattle offense in check and keep it close with an improved offense under Brissett.
Pick: Cardinals +6.5 (-110)
Spread
My Seahawks vs Cardinals betting prediction is on Arizona to cover the spread.
Moneyline
I'm targeting the spread instead of the moneyline in this contest.
Over/Under
I will also be staying away from the total.
