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Lazio vs. Sassuolo Odds & Betting Predictions - September 14, 2025

Lazio at Sassuolo

4:00 pm

Lazio

5-0-1
0
0 - 1

Sassuolo

2-3-2
1

Lazio at Sassuolo Odds

Spread, Total, Moneyline

MatchupOpenSpreadTotalMoneyline
Lazio
5-0-1
-0.5
-0.5-120
o2.5-103
-112
Sassuolo
2-3-2
u2.5
+0.5-118
u2.5-120
+320
location pinSunday 4:00 p.m.
September 14, 2025
Mapei Stadium - Citta del TricoloreReggio Emilia

Prop Odds Comparison

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Line Movement Tracker

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Lazio vs. Sassuolo Public Betting Percentages

Away Logo

Lazio

Public

Home Logo

Sassuolo

95%

Bets%

5%

Money%

Serie A Public Betting Right Arrow

Betting Trends

  • Sassuolo are 1-2 in their last 5 games.
  • Sassuolo are 4-1 in their last 5 games against the spread
  • Sassuolo are 2-2 in their road games against the spread
  • The totals have gone OVER in 4 of Sassuolo' last 5 games
  • The totals have gone OVER in 2 of Sassuolo' 3 last games at home

Matchup History

Against the Spread (ATS) History

overallhomeawayfavoriteunderdog
Sassuolo		5-23-02-21-14-1
Lazio		6-03-03-04-02-0

Over/Under History

overallhome o/uaway o/ufavorite o/uunderdog o/u
Sassuolo		6-12-14-02-04-1
Lazio		3-32-11-22-21-1

Straight-Up (ML) History

overallhomeawayfavoriteunderdog
Sassuolo		2-32-0-10-3-11-11-2-2
Lazio		5-02-0-13-04-01-0-1

Last 5 Matchups

dateopponentscorespreadover/undermoneyline
Aug 29th@CREL 2-3-0.5 LO 2.5CRE +162
Aug 23rdNAPL 0-2+1 LU 2.5NAP +462
May 26th@LAZL 1-1---
May 19thCAGL 0-2---
May 12th@GENL 1-2---

Lazio vs. Sassuolo Injury Updates

Lazio Injuries

  • Danilho Doekhi
    DEF

    Doekhi is injured

    Out Indefinitely

  • Gustav Isaksen
    F

    Isaksen is injured with groin

    Out Indefinitely

Sassuolo Injuries

  • Nemanja Matic
    MID

    Calf/Shin Injury

    Out Indefinitely

  • Armand Lauriente
    F

    Back Injury

    Out

  • Ismael Kone
    MID

    Ismaël Koné is expected to return Early November 2026 from Broken ankle.

    Out

See more SERIEA Injuries Right Arrow
Team Stats

11
Fouls
16
12
Shots
7
7
Corners
3
1
Offsides
0
0
Red Cards
0
3
Yellow Cards
6
3
Shots On Goal
2
58%
Possession Time
42%

Goalkeeping

Lazio vs. Sassuolo Odds Comparison

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See more Serie A Odds Right Arrow

Lazio at Sassuolo Team Totals

MatchupOverUnder
Lazio
5-0-1
N/A
N/A
Sassuolo
2-3-2
N/A
N/A