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Lazio vs. Sassuolo Odds & Betting Predictions - September 14, 2025

Lazio at Sassuolo

4:00 pm

Lazio

1-3
0
0 - 1

Sassuolo

1-3
1

Lazio at Sassuolo Odds

Spread, Total, Moneyline

MatchupOpenSpreadTotalMoneyline
Lazio
1-3
-0.5
-0.5-120
o2.5-103
N/A
Sassuolo
1-3
u2.5
+0.5-118
u2.5-120
N/A
location pinSunday 4:00 p.m.
September 14, 2025
Mapei Stadium - Citta del TricoloreReggio Emilia

Line Movement Tracker

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Lazio vs. Sassuolo Public Betting Percentages

Away Logo

Lazio

Public

Home Logo

Sassuolo

50%

Bets%

50%

Money%

Serie A Public Betting Right Arrow

Betting Trends

  • Sassuolo are 1-3 in their last 5 games.
  • Sassuolo are 2-2 in their last 5 games against the spread
  • Sassuolo are 1-1 in their road games against the spread
  • The totals have gone OVER in 1 of Sassuolo' last 4 games
  • The totals have gone OVER in 0 of Sassuolo' 2 last games at home

Matchup History

Against the Spread (ATS) History

overallhomeawayfavoriteunderdog
Sassuolo		2-21-11-10-12-1
Lazio		1-31-10-21-10-2

Over/Under History

overallhome o/uaway o/ufavorite o/uunderdog o/u
Sassuolo		1-30-21-11-00-3
Lazio		1-31-10-21-10-2

Straight-Up (ML) History

overallhomeawayfavoriteunderdog
Sassuolo		1-31-10-20-11-2
Lazio		1-31-10-21-10-2

Last 5 Matchups

dateopponentscorespreadover/undermoneyline
Aug 29th@CREL 2-3-0.5 LO 2.5CRE +162
Aug 23rdNAPL 0-2+1 LU 2.5NAP +462
May 26th@LAZL 1-1+1.5 WU 2.5LAZ +747
May 19thCAGL 0-2-0.5 LU 2.5CAG +145
May 12th@GENL 1-2+0.5 LO 2.5GEN +210

Lazio vs. Sassuolo Injury Updates

Lazio Injuries

  • Pedro
    F

    Shoulder Injury

    Out Indefinitely

  • Matteo Guendouzi
    MID

    Ankle/Foot Injury

    Out Indefinitely

  • Matias Vecino
    MID

    Vecino is doubtful with muscle

    Doubtful

  • Samuel Gigot
    DEF

    Ankle/Foot Injury

    Out

  • Toma Basic
    MID

    Thigh Muscle Strain

    Out

  • Taty Castellanos
    F

    Suspended

    Out

  • Manuel Lazzari
    MID

    Lazzari is out with muscle

    Out

Sassuolo Injuries

  • Nemanja Matic
    MID

    Calf/Shin Injury

    Out Indefinitely

  • Armand Lauriente
    F

    Back Injury

    Out

  • Yeferson Paz Blandon
    DEF

    Paz Blandon is out with muscle

    Out

See more SERIEA Injuries Right Arrow
Team Stats

11
Fouls
16
12
Shots
7
7
Corners
3
1
Offsides
0
0
Red Cards
0
3
Yellow Cards
6
3
Shots On Goal
2
58%
Possession Time
42%

Goalkeeping

Lazio vs. Sassuolo Odds Comparison

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Could not load odds

See more Serie A Odds Right Arrow

Lazio at Sassuolo Team Totals

MatchupOverUnder
Lazio
1-3
o1.5-105
u1.5-128
Sassuolo
1-3
o0.5-210
u0.5+150