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Liverpool vs Atletico Madrid Prediction, Pick, Champions League Odds

Liverpool vs Atletico Madrid Prediction, Pick, Champions League Odds article feature image
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Arne Slot (Getty Images)

Atletico Madrid (6-2) and Liverpool (7-1) will face off today at 3:00 p.m. EDT at Anfield in Liverpool, England.

Liverpool is favored at a -200 price, with the over/under set at 2.5 (-164o / +127u) goals.

Let's get into my Atlético vs. Liverpool prediction.

Quickslip

Atlético vs. Liverpool Prediction

Pick: Liverpool To Win & Both Teams To Score – Yes
My Atlético vs. Liverpool best bet is on the Liverpool Moneyline and both teams scoring in this matchup.

Atlético vs. Liverpool Odds

Atlético Logo
Wednesday, September 17, 2025
3:00 p.m. EDT
-
Liverpool Logo
Atlético Odds
SpreadTotalMoneyline
+1.5
-182
2.5
-164o / +127u
+500
Liverpool Odds
SpreadTotalMoneyline
-1.5
+125
2.5
-164o / +127u
-200
Odds via bet365. Get up-to-the-minute CHAMPIONS odds here.
bet365 Logo

Atlético vs. Liverpool Projections

Projected Chance of Winning

AtléticoDrawLiverpool
23.3%21.3%55.4%

Projected Total Goals

AtléticoTotal GoalsLiverpool
1.032.761.73

Atlético vs. Liverpool Betting Analysis

After a Champions League campaign curtailed by Paris in the last 16, Liverpool enhanced an already formidable attack with the likes of Florian Wirtz and last-minute acquisition Swedish striker Alexander Isak, who joined for a British record fee.

Diego Simeone’s Atletico Madrid, perennial Champions League qualifiers, have struggled against English clubs, winning just once in their last eight attempts. With aspirations of adding the elusive European crown to his achievements, they remain a dangerous opponent, having scored in 15 of their last 16 group games. 

Atletico Madrid secured a much-needed win over Villarreal at the weekend, scoring two goals in the process. They should carry some attacking threat into this clash, but we are banking on them losing the game while getting on the scoresheet in our Liverpool vs Atletico Madrid predictions. The Reds have dominated recent encounters with Spanish sides, winning their last four group matches, including two victories against Atletico in the 2021/22 season. 

Liverpool beat Arsenal 1-0 in their last match at Anfield, but it was their first clean sheet in front of their own fans in 10 competitive matches. 

Over that period, the Reds have scored an average of two goals per game and conceded 1.1.

Arne Slot has added a wealth of talent to his squad in recent months. However, striking a balance between defence and attack could prove problematic. Liverpool looked defensively fragile when Bournemouth counterattacked on matchday one of the Premier League season. Los Colchoneros have the quality to be successful in transition against the champions of England. 

Diego Simeone’s side has failed to score in just two of their last 10 Champions League away matches. During that run, they have scored an average of 2.1 goals per game. Their last away game in this competition was a 2-1 defeat against Real Madrid. The trip to Anfield could play out similarly.

Pick: Liverpool To Win & Both Teams To Score – Yes

Atlético vs. Liverpool Projected Starting Lineups

Atlético

Oblak; Llorente, Le Normand, Lenglet, Ruggeri; Simeone, Barrios, Koke, Gallagher; Griezmann, Sorloth

Liverpool

Alisson; Frimpong, Konate, Van Dijk, Robertson; Gravenberch, Szoboszlai; Salah, Wirtz, Gakpo; Ekitike

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