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Manchester City vs Villarreal Prediction, Pick, Odds for Tuesday, October 21

Manchester City vs Villarreal Prediction, Pick, Odds for Tuesday, October 21 article feature image
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Pep Guardiola (Imagn Images)

Manchester City (1-0-1) and Villarreal (0-1-1) will face off today at 3:00 p.m. EDT at Estadio de la Ceramica in Villarreal, Spain.

Man City is favored at a -140 price, with the over/under set at 2.5 (-169o / +132u) goals.

Let's get into my Man City vs. Villarreal prediction.

Man City vs. Villarreal Prediction

Pick: Both Teams To Score & Over 2.5 Goals
My Man City vs. Villarreal best bet is on both teams to score and Over 2.5 goals.

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Man City vs. Villarreal Odds

Man City Logo
Tuesday, October 21, 2025
3:00 p.m. EDT
-
Villarreal Logo
Man City Odds
SpreadTotalMoneyline
-0.5
-152
2.5
-169o / +132u
-140
Villarreal Odds
SpreadTotalMoneyline
+0.5
+110
2.5
-169o / +132u
+350
Odds via bet365. Get up-to-the-minute CHAMPIONS odds here.
bet365 Logo

Man City vs. Villarreal Projections

Projected Chance of Winning

Man CityDrawVillarreal
57.4%21.5%21.2%

Projected Total Goals

Man CityTotal GoalsVillarreal
1.902.981.08

Man City vs. Villarreal Betting Analysis

Manchester City looked exposed defensively in its last Champions League game. They face a Villarreal side that has shown plenty of attacking impetus this season, so we are backing both teams to score and the match to see at least three goals as part of our Villarreal vs Manchester City predictions.

City was excellent in the first half of its 2-2 away draw with Monaco. They stormed to a two-goal lead, but looked vulnerable in the second half. The home side finished the game with an xG (expected goals) tally of 1.45, just 0.09 less than City despite the visitors dominating the ball. Villarreal is likely not to dominate possession, but it has the quality to attack City as the Ligue 1 side did.

Pep Guardiola’s side’s defensive struggles in Europe aren’t new. City has kept one clean sheet in 11 European away matches since the start of the 2023/24 season, a 4-0 win over Slovan Bratislava. Those games have seen 4.26 goals on average, with both teams scoring in 11.

Villarreal’s last Champions League match was a thrilling 2-2 home draw against Juventus. That game saw a total of 30 shots, with seven big chances created between both teams. This clash with Manchester City is another that promises goals.

Man City vs. Villarreal Projected Starting Lineups

Man City

Donnarumma; Nunes, Stones, Gvardiol, O'Reilly; Gonzalez; Bobb, Silva, Foden, Doku; Haaland

Villarreal

Tenas; Mourino, Marin, Veiga, Cardona; Gueye, Parejo, Comesana; Pepe, Mikautadze, Buchanan

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