Clemson Tigers Odds

Clemson Tigers 2025 Season Preview

Clemson Tigers football will aim to build off a bounce back season, where they won the ACC and made the College Football Playoff for the first time since 2020.

Clemson posted a 10-4 overall record with a 7-1 mark in ACC last season. Clemson defeated fellow CFP ACC member, SMU, in a thrilling conference title game.

Third-year offensive coordinator Garrett Riley and senior quarterback Cade Klubnik will be central figures in determining if Clemson can ascend back to the top of the college football landscape.

Going into the 2024 season, Klubnik was touted as an under-the-radar Heisman Trophy candidate. Klubnik showed a ton of poise and promise down the stretch - because of that, he was one of the early frontrunners for the 2025-26 Heisman Trophy.

On the other side of the ball, Clemson’s defense projects to be dominant once again. Last season, the opportunistic Tigers had the 13th most takeaways in all of FBS.

Key returning defenders include potential first-round picks T.J. Parker and Peter Woods.

The season opener vs. LSU at home will be a fascinating early measuring stick opportunity. Clemson doesn’t play on the road until its third game on Sept. 13 at Georgia Tech.

Regardless of the slate, for the Tigers to prove last season was a coming-out party, they’ll need Klubnik to continue to develop on offense and while being stingy on defense.

Betting on the Clemson Tigers

Clemson Spread

Betting point spreads are wagers based on the expectation that a team will win or lose by a certain number of points. Here’s an example:

• Clemson -2.5 (-110)
• North Carolina +2.5 (-110)

In this situation, Clemson is favored by 2.5 points against North Carolina. If the Tigers win the game by three or more points, a $100 wager on Clemson would come with a payout of $90.91. If the Tar Heels won the game outright or lost by two points or less, the same $100 wager would net $110 plus the original $100 for a total of $210.

FAQ: Everything you need to know about point spreads

Clemson Over/Unders

Over/under, also called point total, is a wager placed on the combined scoring of a single game. Bookmakers come up with a number and you can either bet the over or — you guessed it — the under. Here’s how it works:

Let's say Clemson plays Virginia Tech and the over/under is set at 65 points. A wager on the over would require the Tigers and Hokies to score 66 total points or more to win. Betting the under is an expectation that the two teams would score 64 or fewer points. It's also possible for the bet to push, which would happen if the game finished with exactly 65 points scored.

FAQ: Betting the point total, explained | What is a push?

Clemson Moneylines

Check out this example:

• Clemson -160
• Miami +180

The minus (-) and plus (+) signs distinguish the favorite from the underdog, making Clemson the favorite in this scenario. Odds can be understood more clearly if you think in terms of $10 or $100 increments. A wager on the Tigers odds would mean every $160 bet nets $100. And it's the opposite for underdogs: Here the Miami moneyline was set at +180, meaning a $100 wager would profit $180.

Moneylines are also commonly used when making parlays, which are multiple bets tied into one. Let’s say you bet on Clemson’s moneyline and a -2.5 point spread, Clemson would need to win by three points for that bet to be successful. The risk may be greater, but so is the reward with increased odds. Use our Odds Calculator to calculate any bet amount or conversion.

FAQ: How to bet on the moneyline | How to make a parlay

Clemson Props

Player props are wagers on a single player, and they're tied to a single stat found in the box score for a game or even the whole season. These are among the most fun to bet on, especially if you're already playing fantasy football and like the player-specific focus it offers. Check out an example below:

• Cade Klubnik 2025 passing yards: 2,850.5

FAQ: Here’s how prop betting works

Clemson Futures

Futures are somewhat similar to prop bets in the way that both are monitored over the course of a season. Except most future bets are focused on end-of-season success. Examples of futures are:

• Clemson Tigers odds to win the ACC
• Clemson Tigers odds to reach the College Football Playoff
• Clemson Tigers odds to win the College Football Playoff
• Cade Klubnik’s odds to win the Heisman Trophy

If you think the Tigers can reach the Playoff, this is the place to bet. These types of bets are called futures, and they're just wagers on things that settle at the end of the year. For a full list of NFL futures, click or tap here.

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