Cardinals vs. Astros Odds & Betting Predictions - February 22, 2026

Cardinals at Astros

6:05 pm

St. Louis Cardinals

@

Houston Astros

MatchupOpenSpreadTotalMoneyline
Cardinals 0-0	N/A	N/A	N/A
Astros 0-0	N/A	N/A	N/A

location pin

Sunday 6:05 p.m.

February 22, 2026

The Ballpark of the Palm BeachesWest Palm Beach

No props found

MLB Public Betting

Astros are 3-2 in their last 5 games.
Astros are 3-2 in their last 5 games against the spread
Astros are 45-36 in their road games against the spread
The totals have gone OVER in 1 of Astros' last 5 games
The totals have gone OVER in 36 of Astros' 81 last games at home

Against the Spread (ATS) History

	overall	home	away	favorite	underdog
Astros	82-80	37-44	45-36	43-60	39-18
Cardinals	80-82	41-40	39-42	25-42	54-40

Over/Under History

	overall	home o/u	away o/u	favorite o/u	underdog o/u
Astros	72-83-7	36-43-2	36-40-5	45-56-2	25-27-5
Cardinals	81-74-7	39-39-3	42-35-4	33-29-5	47-45-2

Straight-Up (ML) History

	overall	home	away	favorite	underdog
Astros	87-75	46-35	41-40	56-47	31-26
Cardinals	78-84	44-37	34-47	33-34	44-50

date	opponent	score	spread	over/under	moneyline
Sep 28th	@LAA	W 6-2	-1.5 W	U 9	HOU -117
Sep 28th	@LAA	W 6-1	-1.5 W	U 9	HOU -146
Sep 27th	@LAA	L 3-4	-1.5 L	U 9	LAA -133
Sep 25th	@ATH	W 11-5	-1.5 W	O 9.5	HOU -119
Sep 25th	@ATH	L 0-6	-1.5 L	U 9	ATH -135

Hayden Wesneski
RP
Wesneski is out with elbow
Out

Naughton
P
Naughton is out with arm
Out
Masyn Winn
SS
Masyn Winn (knee) has been scratched Friday.
Out

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MatchupOverUnder
Cardinals 0-0	N/A	N/A
Astros 0-0	N/A	N/A