Guardians vs. Tigers Odds & Betting Predictions - May 21, 2026

Guardians at Tigers

5:10 pm • CLEG

Cleveland Guardians

Detroit Tigers

pitcher		team	era	w-l
C.Mize			2.43	2-2
J.Cantillo			3.40	3-1

MatchupOpenSpreadTotalMoneyline
Guardians 29-22	-1.5	-1.5+164	o7-120	+100
Tigers 20-30	u7.5	-1.5+172	u7-102	-120

Thursday 5:10 p.m.

May 21, 2026

Comerica ParkDetroit

61°Fahrenheit

0%Rain

11Wind

DET -120

1.2u

Under 4 (F5)-125

1.25u

DET -124 (F5)

1.24u

J.Ramirez o1.5 Hits + Runs + RBIs-123

$1.23

CLE +105

J.Ramirez o1.5 Total Bases+117

$1.00

DET -110

0.55u

Bet to -120

Under 7.5-114

0.57u

Bet to -122

Under 7.5-112

0.56u

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No props found

MLB Public Betting

Tigers are 0-5 in their last 5 games.
Tigers are 3-2 in their last 5 games against the spread
Tigers are 9-17 in their road games against the spread
The totals have gone OVER in 1 of Tigers' last 5 games
The totals have gone OVER in 9 of Tigers' 24 last games at home

Against the Spread (ATS) History

	overall	home	away	favorite	underdog
Tigers	25-25	16-8	9-17	14-14	11-9
Guardians	28-23	16-9	12-14	16-14	12-9

Over/Under History

	overall	home o/u	away o/u	favorite o/u	underdog o/u
Tigers	22-26-2	9-13-2	13-13	12-14-2	9-11
Guardians	26-25	12-13	14-12	15-15	11-10

Straight-Up (ML) History

	overall	home	away	favorite	underdog
Tigers	20-30	13-11	7-19	14-14	6-14
Guardians	29-22	15-10	14-12	18-12	11-10

date	opponent	score	spread	over/under	moneyline
May 20th	CLE	L 2-3	+1.5 W	U 7.5	CLE +102
May 19th	CLE	L 3-4	+1.5 W	U 8	CLE +135
May 18th	CLE	L 2-8	-1.5 L	O 8	CLE -156
May 17th	TOR	L 1-4	+1.5 L	U 7.5	TOR -102
May 16th	TOR	L 1-2	+1.5 W	U 8	TOR -115

Reese Olson
SP
Olson is out with shoulder
Out
Jackson Jobe
SP
Jobe is out with elbow
Out
Trey Sweeney
SS
Sweeney is out with shoulder
Out
Sawyer Gipson-Long
SP
Gipson-Long is out with oblique
Out
Beau Brieske
RP
Brieske is out with groin
Out
Troy Melton
SP
Melton is out with elbow
Out

See more MLB Injuries

PITCHER		W-L	ERA	WHIP	K/9
LJ.Cantillo, P		3-1	3.40	1.351	8.05

HITTERS	AVG	OBP	SLG	HR
1D.Schneemann, 3B	.244	.322	.397	4
2J.Ramirez, DH	.235	.363	.422	8
3C.DeLauter, RF	.274	.361	.470	7
4R.Hoskins, 1B	.192	.353	.375	4
5T.Bazzana, 2B	.304	.429	.406	2
6A.Martinez, LF	.263	.305	.500	9
7S.Kwan, CF	.207	.337	.266	1
8P.Bailey, C	.067	.125	.133	0
9B.Rocchio, SS	.277	.366	.396	4

PITCHER		W-L	ERA	WHIP	K/9
RC.Mize, P		2-2	2.43	1.054	9.49

HITTERS	AVG	OBP	SLG	HR
1M.Vierling, CF	.207	.277	.380	4
2K.McGonigle, 3B	.285	.393	.408	2
3D.Dingler, C	.234	.313	.443	8
4R.Greene, LF	.333	.430	.486	4
5J.Jones, DH	.182	.250	.327	2
6S.Torkelson, 1B	.193	.307	.379	7
7W.Perez, RF	.167	.220	.245	2
8H.Lee, 2B	.207	.258	.328	1
9Z.Short, SS	.000	.278	.000	0