Cubs vs. Reds Odds & Betting Predictions - September 21, 2025

Cubs at Reds

5:40 pm • MARQ+
0 - 1
Starting Pitchers
pitcherteameraw-l
Andrew Abbott logoA.AbbottCincinnati Reds logo2.8710-7
Jameson Taillon logoJ.TaillonChicago Cubs logo3.6811-7

Cubs at Reds Odds

Spread, Total, Moneyline

MatchupOpenSpreadTotalMoneyline
Cubs
52-41
-1.5
+1.5-198
o9+100
+105
Reds
42-50
u9
-1.5+168
u9-121
-126
location pinSunday 5:40 p.m.
September 21, 2025
Great American Ball ParkCincinnati

Prop Odds Comparison

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Line Movement Tracker

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Cubs vs. Reds Public Betting Percentages

Away Logo

Cubs

Public

52%

Bets%

48%

Money%

MLB Public Betting Right Arrow

Matchup History

Against the Spread (ATS) History

overallhomeawayfavoriteunderdog
Reds
49-4323-2426-1915-1234-30
Cubs
40-5317-2923-2425-3715-16

Over/Under History

overallhome o/uaway o/ufavorite o/uunderdog o/u
Reds
52-39-126-2126-18-118-934-29-1
Cubs
50-4325-2125-2232-3018-13

Straight-Up (ML) History

overallhomeawayfavoriteunderdog
Reds
42-5021-2621-2416-1126-38
Cubs
52-4127-1925-2236-2616-15

Last 5 Matchups

dateopponentscorespreadover/undermoneyline
Sep 20thCHCW 6-3+1.5 WU 9CIN -114
Sep 19thCHCW 7-4+1.5 WO 8CIN -110
Sep 18thCHCW 1-0-1.5 LU 8.5CIN -145
Sep 17th@STLW 6-2-1.5 WU 8.5CIN -120
Sep 16th@STLL 0-3-1.5 LU 8STL -123

Reds vs. Cubs Injury Updates

Reds Injuries

    Cubs Injuries

    • Tyler Austin
      1B

      Austin is out with knee

      Out

    • Justin Steele
      SP

      Steele is out with elbow

      Out

    Cubs vs. Reds Box Score
    Cubs Player Stats
    Projected
    PITCHERPCIPKER
    Jameson Taillon logoRJ.Taillon, P82741
    Brad Keller logoRB.Keller, P11110
    HITTERSH-ABRHRRBI
    Nico Hoerner logo1N.Hoerner, 2B0-4000
    Ian Happ logo2I.Happ, LF1-4000
    Seiya Suzuki logo3S.Suzuki, RF1-4000
    Carson Kelly logo4C.Kelly, C0-3000
    Carlos Santana logo5C.Santana, DH1-2000
    Moises Ballesteros logo5M.Ballesteros, PH0-1000
    Moises Ballesteros logo5M.Ballesteros, DH0-1000
    Dansby Swanson logo6D.Swanson, SS1-4000
    Justin Turner logo7J.Turner, 3B0-3000
    Willi Castro logo7W.Castro, PH0-1000
    Michael Busch logo8M.Busch, 1B1-3000
    Kevin Alcantara logo9K.Alcantara, CF1-2000
    Pete Crow-Armstrong logo9P.Crow-Armstrong, PH0-2000
    Pete Crow-Armstrong logo9P.Crow-Armstrong, CF0-2000
    Reds Player Stats
    Projected
    PITCHERPCIPKER
    Andrew Abbott logoLA.Abbott, P864.220
    Nick Martinez logoRN.Martinez, P342.110
    Graham Ashcraft logoRG.Ashcraft, P17110
    Tony Santillan logoRT.Santillan, P23120
    HITTERSH-ABRHRRBI
    TJ Friedl logo1T.Friedl, CF0-4000
    Gavin Lux logo2G.Lux, DH2-4001
    Noelvi Marte logo3N.Marte, RF1-3000
    Spencer Steer logo4S.Steer, 1B0-3000
    Will Benson logo5W.Benson, LF0-3000
    Elly De La Cruz logo6E.De La Cruz, SS1-3000
    Ke'Bryan Hayes logo7K.Hayes, 3B0-3000
    Jose Trevino logo8J.Trevino, C0-3000
    Matt McLain logo9M.McLain, 2B1-3100

    Cubs vs. Reds Odds Comparison

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    Cubs at Reds Team Totals

    MatchupOverUnder
    Cubs
    52-41
    N/A
    N/A
    Reds
    42-50
    N/A
    N/A