Guardians vs. Tigers Odds & Betting Predictions - September 16, 2025

Guardians at Tigers

10:40 pm • CLEG

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Cleveland Guardians

@

Detroit Tigers

pitcher		team	era	w-l
C.Mize			0.00	0-0
J.Cantillo			0.00	0-0

MatchupOpenSpreadTotalMoneyline
Guardians 77-71	N/A	N/A	N/A
Tigers 84-65	N/A	N/A	N/A

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Tuesday 10:40 p.m.

September 16, 2025

Comerica ParkDetroit

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78°Fahrenheit

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0%Rain

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4Wind

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MLB Public Betting

Tigers are 2-3 in their last 5 games.
Tigers are 2-3 in their last 5 games against the spread
Tigers are 30-44 in their road games against the spread
The totals have gone OVER in 5 of Tigers' last 5 games
The totals have gone OVER in 38 of Tigers' 75 last games at home

Against the Spread (ATS) History

	overall	home	away	favorite	underdog
Tigers	71-78	41-34	30-44	48-56	23-20
Guardians	78-70	37-37	41-33	31-30	46-38

Over/Under History

	overall	home o/u	away o/u	favorite o/u	underdog o/u
Tigers	79-63-7	38-32-5	41-31-2	54-44-6	24-18-1
Guardians	64-78-6	34-37-3	30-41-3	31-29-1	32-47-5

Straight-Up (ML) History

	overall	home	away	favorite	underdog
Tigers	84-65	46-29	38-36	63-41	21-22
Guardians	77-71	40-34	37-37	39-22	38-46

date	opponent	score	spread	over/under	moneyline
Sep 13th	@MIA	L 4-6	-1.5 L	O 8.5	MIA -132
Sep 12th	@MIA	L 2-8	-1.5 L	O 7	MIA -199
Sep 11th	@NYY	L 3-9	+1.5 L	O 8.5	NYY +140
Sep 10th	@NYY	W 11-1	+1.5 W	O 8	DET +142
Sep 9th	@NYY	W 12-2	+1.5 W	O 8.5	DET +134

Ben Lively
SP
Lively is out with elbow
Out
John Means
SP
Means is out with elbow
Out

Alex Cobb
SP
Cobb is out with hip
Out
Jose Urquidy
SP
Urquidy is out with arm
Out
Reese Olson
SP
Olson is out with shoulder
Out
Ty Madden
SP
Madden is out with shoulder
Out

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MatchupOverUnder
Guardians 77-71	N/A	N/A
Tigers 84-65	N/A	N/A