Phillies vs. Cubs Odds & Betting Predictions - April 22, 2026

Phillies at Cubs

11:40 pm • NBCS-PH+
@
Starting Pitchers
pitcherteameraw-l
Matthew Boyd logoM.BoydChicago Cubs logo6.751-1
Kyle Backhus logoK.BackhusPhiladelphia Phillies logo5.400-0

Phillies at Cubs Odds

Spread, Total, Moneyline

MatchupOpenSpreadTotalMoneyline
Phillies
8-15
+1.5
+1.5-150
o8-110
+145
Cubs
14-9
u8
-1.5+125
u8-110
-174
location pinWednesday 11:40 p.m.
April 22, 2026
Wrigley FieldChicago
thermometer image55°Fahrenheit
rain image0%Rain
wind image5Wind
Phillies vs. Cubs Expert Picks
Frank Ammirante
Frank Ammirante
Last 30d: 250-294-14 (-2.8u)
Under 4.5 (F5)-125
1.25u
Ryan Minion
Ryan Minion
Last 30d: 226-294-4 (-20.7u)
A.Bohm o1.5 Hits + Runs + RBIs+100
$1.00
D.Swanson o1.5 Hits + Runs + RBIs+112
$1.00
Frank Ammirante
Frank Ammirante
Last 30d: 250-294-14 (-2.8u)
Under 8.5-112
1.12u

Prop Odds Comparison

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No props found

Line Movement Tracker

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Phillies vs. Cubs Public Betting Percentages

Away Logo

Phillies

Public

24%

Bets%

76%

Money%

MLB Public Betting Right Arrow

Matchup History

Against the Spread (ATS) History

overallhomeawayfavoriteunderdog
Cubs
11-127-74-57-94-3
Phillies
4-192-132-64-150-4

Over/Under History

overallhome o/uaway o/ufavorite o/uunderdog o/u
Cubs
13-107-76-38-85-2
Phillies
11-11-18-6-13-510-8-11-3

Straight-Up (ML) History

overallhomeawayfavoriteunderdog
Cubs
14-99-55-410-64-3
Phillies
8-155-103-58-110-4

Last 5 Matchups

dateopponentscorespreadover/undermoneyline
Apr 21stPHIW 7-4-1.5 WO 8.5CHC -128
Apr 20thPHIW 5-1+1.5 WU 7.5CHC -114
Apr 19thNYMW 2-1-1.5 LU 8CHC -139
Apr 18thNYMW 4-2+1.5 WU 8.5CHC -118
Apr 17thNYMW 12-4-1.5 WO 10CHC -152

Cubs vs. Phillies Injury Updates

Cubs Injuries

  • Tyler Austin
    1B

    Austin is out with knee

    Out

  • Justin Steele
    SP

    Steele is out with elbow

    Out

  • Jordan Wicks
    SP

    Wicks is out with arm

    Out

Phillies Injuries

  • Zack Wheeler
    SP

    Wheeler is out with shoulder

    Out

  • Max Lazar
    RP

    Lazar is out with oblique

    Out

  • Andrew Painter
    SP

    Andrew Painter was seen walking out to bullpen, he won't start but could be available in relief.

    Questionable

  • Steward Berroa
    RF

    Berroa is out with shoulder

    Out

Phillies vs. Cubs Starting Lineups
Phillies Starting Lineup
Projected
PITCHERW-LERAWHIPK/9
Kyle Backhus logoLK.Backhus, P0-05.401.20012.15
HITTERSAVGOBPSLGHR
Trea Turner logo1T.Turner, SS.234.294.3402
Kyle Schwarber logo2K.Schwarber, DH.217.363.5548
Bryce Harper logo3B.Harper, 1B.274.365.5365
Felix Reyes logo4F.Reyes, LF.286.286.7141
Adolis Garcia logo5A.Garcia, RF.210.301.3332
J.T. Realmuto logo6J.Realmuto, C.259.344.3521
Alec Bohm logo7A.Bohm, 3B.128.205.1791
Brandon Marsh logo8B.Marsh, CF.276.300.4082
Edmundo Sosa logo9E.Sosa, 2B.219.265.3751
Cubs Starting Lineup
Projected
PITCHERW-LERAWHIPK/9
Matthew Boyd logoLM.Boyd, P1-16.751.17916.39
HITTERSAVGOBPSLGHR
Nico Hoerner logo1N.Hoerner, 2B.326.402.5334
Alex Bregman logo2A.Bregman, 3B.245.327.3402
Ian Happ logo3I.Happ, LF.244.367.5126
Seiya Suzuki logo4S.Suzuki, RF.256.396.3591
Michael Busch logo5M.Busch, 1B.173.269.1980
Miguel Amaya logo6M.Amaya, C.243.364.3511
Moises Ballesteros logo7M.Ballesteros, DH.378.431.6003
Dansby Swanson logo8D.Swanson, SS.187.337.4005
Pete Crow-Armstrong logo9P.Crow-Armstrong, CF.225.281.3031

Phillies vs. Cubs Odds Comparison

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Phillies at Cubs Team Totals

MatchupOverUnder
Phillies
8-15
N/A
N/A
Cubs
14-9
N/A
N/A