The Kentucky Wildcats take on the Louisville Cardinals in Louisville, KY. Tip-off is set for 8 p.m. ET on ESPN.
Louisville is favored by -3 points on the spread with a moneyline of -165. The total is set at 175 points.
Here’s my Kentucky vs. Louisville predictions and college basketball picks for November 11, 2025.
Kentucky vs Louisville Prediction
My Pick: Over 173.5
My Kentucky vs Louisville best bet is on the over. For all of your college basketball bets, be sure to find the best lines by using our live NCAAB odds page.
Kentucky vs. Louisville Odds
| Kentucky Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+3 -105 | 175 -115 / -105 | +140 |
| Louisville Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-3 -115 | 175 -115 / -105 | -165 |
- Kentucky vs Louisville spread: Louisville -3
- Kentucky vs Louisville over/under: 175 points
- Kentucky vs Louisville moneyline: Kentucky +140, Louisville -165
Kentucky vs Louisville College Basketball Betting Preview
Kentucky Basketball
Mark Pope's team entered the season with the second-best odds of winning the SEC.
Kentucky has dominated the Battle of the Bluegrass, but comes into this contest as the underdog. The Cats lead the all-time head-to-head series, 40-17.
The Wildcats are off to a fast 2-0 start, winning their first two games by a combined 74 points.
Sophomore guard Collin Chandler leads the team with 14.5 points per game.
Newark, New Jersey, native Otega Oweh led the team in scoring last season and has averaged 14 points and four rebounds over his first two games.
All-SEC Preseason team guard Jaland Lowe made his Kentucky debut on Friday, and he scored six points in 18 minutes.
Louisville Basketball
The Cardinals will attempt to earn a statement win on Tuesday.
Pat Kelsey is 0-2 in his early career against this Kentucky team.
Kelsey has this program back on track, though, leading Louisville to the Big Dance last season for the first time since 2019. Louisville's 27 wins were the program's most in a season since 2014.
The Cardinals have started this season with back-to-back comfortable wins over South Carolina State (104-45) and Jackson State (106-70).
Washington, D.C. native Khani Rooths is leading the Cardinals with 18 points and 8.5 rebounds a night. Senior Ryan Conwell has added 15.5 points and 5.5 boards over the first couple of games.
Kasean Pryor (knee) is expected to be active for this contest. Pryor was quoted as guaranteeing a win over the Wildcats this week.
Kentucky vs. Louisville Betting Analysis
We'll see two premier offensive teams in action on Tuesday.
While it's extremely early in the season, both teams rank in the top 12 in adjusted offensive efficiency.
I expect the pace of this game to favor the over, as we should see a fast-paced, up-and-down contest. Both teams feature elite guard play that will push the tempo.
The Cats and Cardinals are both high-volume 3-point shooting teams, boasting rosters with capable shooters.
I expect both offenses to show what they're capable of in a primetime rivalry on Tuesday.
My Pick: Over 173.5
