Iowa State Cyclones Odds

Iowa State Cyclones 2025-26 Season

Iowa State enters the final stretch of the 2026 season as a dominant force in the Big 12, consistently ranking within the top-10. Under fifth-year head coach T.J. Otzelberger, the Cyclones have assembled one of the most productive regular seasons in program history, beginning the campaign with a historic 16–0 start. This is the best opening run in school history, highlighted by a statement 23-point road win over then-No. 1 Purdue in December. Despite a late-February skid with losses to Texas Tech and Arizona, the Cyclones reclaimed their momentum with a decisive 86–65 Senior Day victory over Arizona State, securing the No. 5 seed and a double-bye in the Big 12 Tournament.

The team’s identity remains rooted in a top-tier defense, but this year's squad features a remarkably versatile offensive attack. Junior forward Milan Momcilovic leads the scoring while senior Joshua Jefferson has become the ultimate point-forward, surprisingly leading the team in assists per game. The engine of the team continues to be senior guard Tamin Lipsey, whose veteran leadership and steady scoring has kept the Cyclones steady in the nation's toughest conference.

Overall, the Cyclones have as good a shot at making noise this March as anyone. Do you like ISU's chances of making the semifinal, or even winning it all? Check the latest college basketball odds to place your bets today, where we've got every NCAAB team covered. 

Betting on the Iowa State Cyclones

The Iowa State Cyclones aren't necessarily the top-ranked favorites heading into tournament season, but the team is still strong. If you live in a legal online sports betting state, read on for a brief breakdown of the most popular types of college basketball bets you can make, whether on the Cyclones, their players, or any other NCAAB team you find interesting.

Fortunately, online sports betting became legal in Iowa back on January 1st, 2021, so options are plentiful! Popular NCAAB betting markets include:

• Moneyline
• Point Spread
• Over/Under
• Props
• Futures

First time betting on college basketball? Are you new to betting in general? Please consult our NCAAB betting guide for everything you need to know before placing any wagers. 

Iowa State Moneyline Bet

A moneyline bet requires a bettor to correctly pick the winner of the game. Pick the right team, and you will win the bet. The amount of money you can win on any given moneyline bet is determined by both the current odds and your wager amount. Here's an example using moneyline odds from a game between ISU and Oklahoma State.

• OSU (-170)
• ISU (+145)

OSU is favored to win this game, indicated by the minus sign (-) of the team's odds. ISU is the underdog, represented by the plus sign (+) next to the team's odds. The moneyline number signifies the potential payout for each team; therefore, someone betting on OSU would have to bet $170 to win $100, whereas a bettor would win $145 with a wager of just $100 on ISU.

Iowa State Point Spread Bet

Players also have the option of placing a point spread wager on the Cyclones. This betting market focuses on correctly selecting the margin of victory by a particular team, rather than simply who wins. Here's the same ISU vs. OSU matchup as an example.

• OSU -3.5 (-110)
• ISU +3.5 (-110)

Oddsmakers set a margin of victory total known as the spread. In this game, OSU's point spread is set to -3.5, meaning the team must win by four or more points to beat the spread. On the other hand, a bet on ISU can cash two different ways. The Cyclones would either have to win the game outright (by any point spread), or lose by three points or less. 

Point spread wagers have an additional element known as 'the juice' or 'the vig', which means a percentage of each bet is paid to the house (aka the sportsbook). The amount of this cut is typically indicated next to the point spread, which is then used to determine the total payout. 

Point spread odds often mirror each other, meaning a winning bet on either OSU or ISU would earn a $100 profit for every $110 risked

Iowa State Over/Under Bet

Betting on over/under totals means predicting whether the cumulative final score between both teams. Unlike moneyline and point spread markets, this means the winner or loser of the game is irrelevant. Simply predict if the total combined final score will be higher or lower than the number set by oddsmakers. In this example, a sportsbook has set the over/under total for OSU vs. ISU at 127.5 points.

• Over 127.5 points (-110)
• Under 127.5 points (-110)

Whether betting on the over or the under of this market, a player would win $100 for every $110 bet on the winning side. Note, the juice/vig comes into play with over/unders as well. 

Iowa State Prop Bet

For those ISU fans that have a particular favorite player, prop bets are a great way to show your support. Oddsmakers set lines on certain player statistics, giving bettors the opportunity to guess whether those players will go over or under the set line to win money. 

Popular prop bets include how many points a player will score, who will score first, how many rebounds a player will get, and more! For example, if you were to place a prop bet on Joshua Jefferson getting over/under 4.5 assists, the bet would hit if he recorded 5 or more. 

Iowa State Futures Bet

If you like ISU’s odds to make the quarters, semis, or even win the NCAA Tournament, you can place a wager through a futures bet. As it sounds, a futures bet is a wager on an event result typically occuring later on in the season. 

Since futures are naturally hard to predict, the payouts are much higher than a typical wager. For example, if the Cyclones odds of winning the NCAA Tournament were +2000, a player would win $2,000 for every $100 wager if ISU went all the way.

How to Bet on the Iowa State Cyclones with Traditional Sportsbooks

Sports betting is legal in the state of Iowa, and many big players operate within the state. BetMGM, Caesars, and FanDuel are just some of the most popular operators available, and Action Network has plenty of promo codes available for your disposal. Check out our sportsbook reviews and decide which books are best for you, and don't forget our Iowa betting page if you want to get more state specific.

Not from Iowa? Check out our legal online sports betting states page, or visit our latest NCAAB betting picks page if your account is set up and you'd just like some advice.

How to Bet on the Iowa State Cyclones with Kalshi

The popularity of prediction markets like Kalshi continues to skyrocket, making it another great way to place NCAAB bets. Simply put, Kalshi lets users trade on event contracts involving several markets that transcent sports alone including politics and pop culture.

Another perk is the accessibility of prediction market apps across the US. Traditional online sportsbooks are only legal in a handful of states, whereas prediction markets betting is available in every states since it's regulated at a federal level. Feel free to use our Kalshi promo code if you want to give it a try!