Kentucky vs. Iowa State Odds & Betting Predictions - March 22, 2026

Kentucky at Iowa State

6:45 pm • CBS

Kentucky Wildcats

Iowa State Cyclones

MatchupOpenSpreadTotalMoneyline
Kentucky 21-13	+4.5	+4.5-107	o145.5-110	+180
Iowa State 27-7	u146	-4.5-115	u145.5-110	-220

Sunday 6:45 p.m.

March 22, 2026

Enterprise CenterSt. Louis

ISU -4.5-113

UK +5.5-115

0.45u

Some speculation here but don’t think Jefferson plays which would make this a very good number to have in pocket

UK +5.5-115

$57.50

Half in for now

No props found

NCAAB Public Betting

Iowa State are 3-2 in their last 5 games.
Iowa State are 4-1 in their last 5 games against the spread
Iowa State are 8-5 in their road games against the spread
The totals have gone OVER in 2 of Iowa State' last 5 games
The totals have gone OVER in 12 of Iowa State' 21 last games at home

Against the Spread (ATS) History

	overall	home	away	favorite	underdog
Iowa State	20-14	12-9	8-5	15-9	2-1
Kentucky	17-17	10-12	7-5	7-8	6-6

Over/Under History

	overall	home o/u	away o/u	favorite o/u	underdog o/u
Iowa State	14-19-1	12-9	2-10-1	8-15-1	1-2
Kentucky	17-17	11-11	6-6	7-8	5-7

Straight-Up (ML) History

	overall	home	away	favorite	underdog
Iowa State	27-7	N/A	N/A	19-5	1-2
Kentucky	21-13	N/A	N/A	11-4	3-9

date	opponent	score	spread	over/under	moneyline
Mar 20th	TNST	W 108-74	-25 W	O 147.5	ISU -10000
Mar 13th	@ARIZ	L 80-82	+3 W	O 144.5	ARIZ +142
Mar 12th	@TTU	W 75-53	-7 W	U 143.5	ISU -298
Mar 11th	ASU	W 91-42	-13.5 W	U 148.5	ISU -1200
Mar 7th	ASU	W 86-65	-16.5 W	O 148.5	ISU -2100

Joshua Jefferson
F
Jefferson is doubtful with ankle
Doubtful

Jaland Lowe
G
Lowe is out for season with arm
Out for Season
Jayden Quaintance
F
Quaintance is out with knee
Out

See more NCAAB Injuries

Kentucky

Iowa State

28-60 (47%)

Field Goals

29-60 (48%)

16-22 (73%)

Free Throws

13-20 (65%)

8-23 (35%)

9-23 (39%)

33.94

Rebounds

32.38

Assists

17.2

9.91

Turnovers

9.91

7.15

Steals

8.97

4.41

Blocks

2.71

18.44

Fouls

15.97

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See more NCAAB Odds

MatchupOverUnder
Kentucky 21-13	N/A	N/A
Iowa State 27-7	N/A	N/A

Kentucky vs. Iowa State Odds & Betting Predictions - March 22, 2026

Kentucky at Iowa State

Kentucky Wildcats

Iowa State Cyclones

Kentucky at Iowa State Odds

Spread, Total, Moneyline

Prop Odds Comparison

Line Movement Tracker

Kentucky vs. Iowa State Public Betting Percentages

Kentucky

Public

Iowa State

Bets%

Money%

Betting Trends

Matchup History

Against the Spread (ATS) History

Over/Under History

Straight-Up (ML) History

Last 5 Matchups

Iowa State vs. Kentucky Injury Updates

Iowa State Injuries

Kentucky Injuries

Kentucky vs. Iowa State Odds Comparison

Kentucky at Iowa State Team Totals