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The Arizona Wildcats take on the West Virginia Mountaineers in Morgantown, W. Va. Kickoff is set for 12:00 p.m. EDT on TNT.
Arizona is favored by -3.5 points on the spread with a moneyline of -165. The total is set at 61.5 points.
Here’s my Arizona vs. West Virginia prediction and college football pick for Saturday, October 10, 2026.
Arizona vs West Virginia Prediction
- Arizona vs. West Virginia Pick: West Virginia +3 or Better
My West Virginia vs. Arizona best bet is on West Virginia to cover the spread. Find the best line available on our live NCAAF odds page. And be sure to download the Action Network app for additional picks and analysis.
Arizona vs West Virginia Odds
| Arizona Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-3.5 -108 | 61.5 -110o / -110u | -165 |
| West Virginia Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+3.5 -120 | 61.5 -110o / -110u | +135 |
- Arizona vs West Virginia point spread: Arizona -3.5 (-108), West Virginia +3.5 (-120)
- Arizona vs West Virginia over/under: 61.5 (-110o / -110u)
- Arizona vs West Virginia moneyline: Arizona -165, West Virginia +135
Arizona vs West Virginia College Football Preview
This particular handicap isn't rocket science.
I simply wanted a field goal (better numbers out there at the time of writing) with the home 'Eers hosting an Arizona team traveling across the country for a noon ET kick for its third road game in five weeks following a late-night finish last Saturday.
Additionally, Arizona will be without its starting tight end and all three starting wide receivers, which should provide an enormous boost to a struggling West Virginia secondary that would've been completely overmatched against this Wildcat passing attack at full strength.
On the other side of the ball, West Virginia has had one of the most explosive offenses in the country (99th percentile) to start 2026 against a more difficult schedule than Arizona.
That could be very problematic for a Wildcat defense that has really struggled in that department (10th percentile).
And it's not like Arizona has faced a gauntlet of explosive offenses in Northern Arizona, BYU, Cincinnati, Washington State, and Northern Illinois. It even struggled to limit those big plays against NIU and Wazzu's broken offenses.
WVU has the horses to fully take advantage of a banged-up linebacker room and a secondary that lost five players to the NFL.
I believe the Wildcats are getting too much credit for destroying a completely overrated Cincinnati bunch in a brutal situational spot.
I project Arizona as less than a field-goal favorite after adjusting for the travel spot and injuries, so give me the 'Eers at a field goal or better.
Pick: West Virginia +3 or Better
