The Duke Blue Devils take on the UConn Huskies in East Hartford, Connecticut. Kickoff is set for 3:30 p.m. EST on CBS Sports Network.
Duke is favored by 9 points on the spread with a moneyline of -330. The total is set at 65.5 points.
Here’s my Duke vs. UConn prediction and college football picks for Saturday, November 8, 2025.
Duke vs UConn Prediction
- Duke vs. UConn Pick: UConn +10.5 or Better
My UConn vs. Duke best bet is on the Huskies. Find the best line available on our live NCAAF odds page.
Duke vs UConn Odds
| Duke Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-9 -110 | 65.5 -110o / -110u | -330 |
| UConn Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+9 -110 | 65.5 -110o / -110u | +265 |
- Duke vs UConn point spread: Duke -9 (-110), UConn +9 (-110)
- Duke vs UConn over/under: 65.5 (-110o / -110u)
- Duke vs UConn moneyline: Duke -330, UConn +265
Duke vs UConn Pick
Here's a fun trivia question. Name the only five teams that haven't lost a game in regulation in 2025.
If you said UConn as one of those five, you'd be correct (along with Louisville, Indiana, Ohio State, and Texas A&M). The Huskies have three losses on the season, but all three came in overtime.
They've been much friskier than I had anticipated coming into the season after some of the losses they suffered on both sides of the ball.
It's just a very well-coached team under Jim Mora and Matt Brock, one of the most unheralded defensive coordinators in the country.
Led by quarterback Joseph Fagnano (who has 25 touchdowns and no interceptions!), this UConn offense should find success against a struggling (and shorthanded) Duke secondary that ranks in the bottom 20 nationally in Passing Success Rate allowed.
Adjusting for opponent, the Blue Devils' defense rates as a bottom-10 Power 4 unit overall.
Duke can get pressure under Manny Diaz as usual, but UConn's offensive line has done an outstanding job in pass protection with the fifth-lowest pressure rate allowed.
Fagnano has also done a fantastic job in limiting negative plays.
The Blue Devils are an inferior tackling team as well, which has caused significant issues after the catch. The Huskies are ideally suited to take full advantage.
The Duke offense will undoubtedly put up its fair share of points. Quarterback Darian Mensah, whose 25:2 touchdown-to-interception ratio isn't too shabby either, has had a fantastic first season in Durham.
However, the UConn defense has been much stronger against the pass. The Huskies can generate pressure and mix up coverages extremely well on the back end to confuse opposing signal-callers.
The run defense is pretty porous (especially against mobile quarterbacks), but Mensah doesn't really run in a very pass-heavy offense.
Most importantly, this is just an atrocious situational spot for Duke. How focused will it be to travel up north for a November nonconference game following a last-second, miraculous (7% post-game win expectancy) road win over Clemson?
The Blue Devils also host Virginia next week in a game that will likely determine their ACC title chances. As a result, this game really doesn't mean much.
Staying healthy and escaping with a win would certainly suffice for Diaz and company, but don't sleep on the Huskies having a shot to pull off this upset. They did go down to Durham last year and played Duke super close, losing 26-21.
Pick: UConn +10.5 or Better
