The SMU Mustangs take on the Boston College Eagles in Chestnut Hill, Massachusetts. Kickoff is set for 12:00 p.m. EST on ACC Network.
SMU is favored by -10.5 points on the spread with a moneyline of -415. The total is set at 55.5 points.
Here’s my SMU vs. Boston College prediction and college football picks for Saturday, November 8, 2025.
SMU vs Boston College Prediction
- SMU vs. Boston College Pick: Boston College +10.5 or Better
My Boston College vs. SMU best bet is on the Eagles. Find the best line available on our live NCAAF odds page.
SMU vs Boston College Odds
| SMU Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-10.5 -110 | 55 -110o / -110u | -400 |
| Boston Col Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+10.5 -110 | 55 -110o / -110u | +320 |
- SMU vs Boston College point spread: SMU -10.5 (-110), Boston College +10.5 (-110)
- SMU vs Boston College over/under: 55.5 (-110o / -110u)
- SMU vs Boston College moneyline: SMU -40, Boston College +320
SMU vs Boston College Pick
This is a brutal spot for SMU. After three straight hard-fought games, the Mustangs have to travel up north for an early kick following one of the biggest home wins this century in overtime against Miami.
We already saw this team come out completely flat in a similar spot at Wake Forest after an upset win over Clemson.
I wouldn't be surprised if it comes out a bit lethargic for its sixth game in six weeks, with a much-needed bye on deck to get healthier.
Plus, SMU hasn't looked right for most of the season. In fact, the Mustangs have been outgained on the season despite owning a 6-3 record.
In back-to-back home games against lowly Syracuse (with a since-benched quarterback) and Stanford, SMU got outgained by three yards in total. It has really benefited from a nation-leading +2.4 takeaways per game, which likely isn't sustainable.
Even last week's victory over Miami likely had more to do with the undisciplined play of the Hurricanes, who committed a dead-ball personal foul on 4th-and-8 in the final minutes to keep the Mustangs alive.
I'm not sure quarterback Kevin Jennings is fully healthy, and the run game has been pretty abysmal after the offseason departure of Brashard Smith. While the run defense remains stout, the Mustangs can be attacked through the air.
I also believe Boston College is a bit undervalued in the market, in large part due to health. The Eagles had one of the most injury-ravaged rosters in the entire country over the first half of the season, which led to predictably disastrous results.
However, they have since gotten much healthier, resulting in much better outcomes.
Over the past two weeks, against a pair of potential CFP participants in Notre Dame and Louisville, BC trailed by only one possession in the fourth quarter.
At 1-8, there's always risk BC checks out, but I didn't see that last week after a tough loss vs. Louisville that ended its bowl hopes.
And I certainly don't expect that this week in the Red Bandana game — one of my favorite recent college football traditions. RIP to the legendary Welles Crowther.
Pick: Boston College +10.5 or Better
