The South Carolina Gamecocks take on the Ole Miss Rebels in Oxford, Mississippi, on Saturday, Nov. 1. Kickoff is set for 7 p.m. ET on ESPN.
Ole Miss is favored by 12.5 points on the spread with a moneyline of -500. South Carolina, meanwhile, enters as a +12.5 underdog and is +375 on the moneyline to pull off the upset. The over/under sits at 55.5 total points.
Here’s my South Carolina vs. Ole Miss prediction and college football picks for Saturday, November 1.
South Carolina vs Ole Miss Prediction
- South Carolina vs. Ole Miss Pick: Ole Miss -12.5
My Ole Miss vs. South Carolina best bet is on the Rebels to cover the spread. Find the best line available on our live NCAAF odds page.
South Carolina vs Ole Miss Odds
| South Carolina Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+12.5 -110 | 55.5 -110o / -110u | +375 |
| Ole Miss Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-12.5 -110 | 55.5 -110o / -110u | -500 |
- South Carolina vs Ole Miss Spread: Ole Miss -12.5, South Carolina +12.5
- South Carolina vs Ole Miss Over/Under: 55.5 Points
- South Carolina vs Ole Miss Moneyline: South Carolina +375, Ole Miss -500
South Carolina vs Ole Miss College Football Betting Preview
South Carolina Gamecocks Betting Preview: Can't Keep Up
This has been a frustrating season for South Carolina.
The Gamecocks are 3-5 overall and just 1-5 in SEC play, and the metrics show why.
Offensively, they’ve been completely out of rhythm, ranking 123rd in Success Rate, 131st in Finishing Drives and 104th in Havoc allowed.
They struggle to stay ahead of schedule, can’t protect the quarterback and don’t have the explosive plays to compensate. In fact, they rank 51st in explosiveness, which is mediocre for a team that’s trailing often.
The defense hasn’t been much better.
South Carolina ranks 88th in Success Rate allowed, 81st in Finishing Drives allowed and 120th on third downs. It hasn't been able to get off the field or stop big plays, giving up chunk yardage to every SEC opponent it's faced.
Even when the front seven creates early-down pressure, breakdowns in coverage or missed tackles wipe out the gains.
The Gamecocks have faced a tough schedule, but the lack of growth is what stands out most. After last week’s gut-punch loss to Alabama — a game they led deep into the fourth quarter — this is a team that looks emotionally spent.
When you combine a bad defense, a broken offense and a deflated locker room, it’s hard to envision them matching Ole Miss’ energy or execution on the road.
Ole Miss Rebels Betting Preview: Chambliss Locked In
Ole Miss has quietly turned into one of the most efficient and well-rounded offenses in the SEC.
The Rebels rank 21st nationally in Offensive Success Rate, 12th in Finishing Drives and ninth in tempo, which makes them both disciplined and dangerous.
They play fast but not recklessly, staying on schedule, spreading the ball and capitalizing on nearly every red-zone opportunity.
The driving force behind it all is quarterback Trinidad Chambliss, who continues to be one of the most underrated signal-callers in the country.
He ranks fourth among qualifying QBs in big-time throw to turnover-worthy play ratio, a sign of a passer who creates explosive plays while avoiding mistakes.
Chambliss has brought balance to an offense that once leaned entirely on tempo and creativity; now it’s precision-based, methodical when needed and lethal when defenses overcommit.
Chambliss is supported by a ground game that ranks 39th in explosiveness and a line that’s kept him clean and ranks 10th in Havoc allowed.
Together, they’ve built one of the most reliable offenses in college football.
This is a unit that doesn’t beat itself, sitting top-15 in Finishing Drives and top-20 in third-down conversion rate. That makes it a nightmare for struggling defenses.
Against a South Carolina unit that ranks near the bottom of the SEC in most defensive categories, Ole Miss should have its way both on the ground and through the air.
I also want to take a ball-knower's moment here and call this out from my Week 4 article:
"Despite the breakout performance, Kiffin appears set to roll with Austin Simmons this weekend.
"This is a puzzling move. While the sample size is admittedly small, both quarterbacks have posted identical Big-Time Throw (BTT) rates. However, Simmons has five Turnover-Worthy Plays (TWPs) to Chambliss’ zero — a stat that should give pause."
Don't be surprised to hear Chambliss be the first quarterback called in the NFL Draft in April should he declare, or as the Heisman winner (+3000 at DraftKings) if Ole Miss wins out this season.
South Carolina vs Ole Miss Pick, Betting Analysis
This matchup is about two teams headed in opposite directions, both statistically and emotionally.
Ole Miss is riding high after a massive upset at home that effectively ended Brian Kelly’s tenure at LSU — a statement win that solidified its place as one of the SEC’s top teams.
South Carolina, meanwhile, comes limping into Oxford at 1-5 in conference play, fresh off a heartbreaking collapse against Alabama. The contrast in momentum couldn’t be sharper.
On paper, the Rebels are elite where it matters most.
They’re top-15 in Finishing Drives, while South Carolina’s defense ranks in the bottom 20. They’re top 25 in Success Rate, while the Gamecocks offense sits 123rd.
Chambliss’s efficiency and composure mean turnovers are unlikely, and his balance between aggression and control gives this Ole Miss offense an edge few defenses can handle.
Emotionally, this is also a classic “bounce-forward” spot for Ole Miss and a chance to prove its LSU win wasn’t a one-off.
Lane Kiffin’s team tends to play its best when confidence is high, and this setup mirrors previous post-upset blowouts under his tenure.
The Rebels’ tempo and rhythm should expose South Carolina’s thin secondary, while their defensive front, led by a top-20 Havoc unit, will keep the Gamecocks in constant long-yardage situations.
South Carolina may hang around for a quarter, but the cracks always show once Ole Miss settles in.
The Gamecocks don’t have the defensive speed to contain Chambliss or the offensive line to sustain drives against an aggressive Rebel front.
Once Ole Miss builds a two-score lead, its tempo and offensive efficiency make it nearly impossible for a team like South Carolina to claw back.
Pick: Ole Miss -12.5
South Carolina vs Ole Miss Betting Trends
