The Troy Trojans take on the Clemson Tigers in Clemson, SC. Kickoff is set for 3:30 p.m. ET on ACC Network.
Clemson is favored by -33.5 points on the spread with a moneyline of -6600. The total is set at 51.5 points.
Here’s my Troy vs. Clemson predictions and college football picks for Saturday, September 6, 2025.
Troy vs Clemson Prediction
- Troy vs. Clemson Pick: Over 51.5
My Clemson vs. Troy best bet is on the over. Find the best line available on our live NCAAF odds page.
Troy vs Clemson Odds
| Troy Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+33.5 -110 | 51.5 -114o / -106u | +1650 |
| Clemson Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-33.5 -110 | 51.5 -114o / -106u | -6600 |
- Troy vs Clemson point spread: Clemson -33.5
- Troy vs Clemson over/under: 51.5 points
- Troy vs Clemson moneyline: Troy +1650, Clemson -6600
Troy vs Clemson Pick, Betting Analysis
In one of the more marquee matchups of Week 1, Clemson lost at home to LSU, 17-10. The Tigers dropped from four to eight in the latest college football AP Poll, and now they are attempting to bounce back against Troy.
The Tigers are favored by nearly 34 points in this affair, so there's no worries about them losing back-to-back. However, this is looking like a get-right game, giving us a potential look at the over.
More importantly, multiple systems are propped up on this play, including Evan Abrams' "Unfamiliar Blowout Overs," which has a 17% return on a investment since its inception and is already 3-0 this season.
"Unfamiliar Blowout Overs" is a college football system that identifies high scoring potential in non-conference games where mismatches often lead to inflated point totals.
During the regular season, when the home team is heavily favored by more than 30 points, the talent gap is wide enough that scoring can come quickly and often. Non-conference opponents are less familiar with each other’s schemes, which reduces defensive preparation and increases the likelihood of big plays.
By focusing on games where the closing total is below 60 (which this game is), the system finds situations where expectations are modest despite the conditions favoring offense.
In these contests, the stronger team can pile on points while the underdog often contributes through late scoring in garbage time, pushing results over the total more often than anticipated.
Pick: Over 51.5
