The UConn Huskies take on the Buffalo Bulls in Buffalo, New York. Kickoff is set for 3:30 p.m. ET on ESPN+.
UConn is favored by -4 points on the spread with a moneyline of -180. The total is set at 49.5 points.
Here’s my UConn vs. Buffalo prediction and college football picks for Saturday, September 27, 2025.
UConn vs Buffalo Prediction
- UConn vs. Buffalo Pick: Buffalo ML +146
My Buffalo vs. UConn best bet is on the Bulls moneyline. Find the best line available on our live NCAAF odds page.
UConn vs Buffalo Odds
| UConn Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-4 -110 | 49.5 -110o / -110u | -180 |
| Buffalo Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+4 -110 | 49.5 -110o / -110u | +150 |
- UConn vs Buffalo point spread: UConn -4
- UConn vs Buffalo over/under: 49.5 points
- UConn vs Buffalo moneyline: UConn -180, Buffalo +150
UConn vs Buffalo Pick, Betting Analysis
UConn is 2-2 this season with both of its losses (Syracuse, Delaware) coming in overtime.
Meanwhile, Buffalo also has two losses on the 2025 campaign, including one against Troy at home last week in which the Trojans scored 21 points in the fourth quarter to overcome a 17-point deficit.
So, how should we approach this UConn vs. Buffalo game as part of college football's Week 5?
Our Evan Abrams has two systems lighting up on Buffalo moneyline, including one — "Normal Rest Contrarian Dogs" — with a 2025 return on investment (ROI) of 28%.
In college football, normal rest contrarian 'dogs are teams that have had a full week or slightly longer to prepare, yet still face significant betting line movement against them.
When the spread shifts multiple points from open to close, it often signals strong market confidence in the favorite.
However, these 'dogs, playing in the heart of the season from September through November or into the postseason, benefit from preparation time and game planning.
With spreads in the moderate to large range, they're capable of upsetting inflated odds, especially when the market’s perception has tilted too far, creating hidden value on the moneyline.
Thus, Buffalo moneyline is the value play for this one.
Pick: Buffalo ML +146
