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Cardinals vs. Titans Week 1 Opening Odds, Line: Arizona Cardinals Week 1 Road Dogs vs. Titans

Cardinals vs. Titans Week 1 Opening Odds, Line: Arizona Cardinals Week 1 Road Dogs vs. Titans article feature image

Jevone Moore/Icon Sportswire via Getty Images. Pictured: Kyler Murray

Cardinals vs. Titans Odds

Cardinals Odds +2.5
Titans Odds -2.5 
Over/Under 52
Date Sunday, Sept. 12
Time 1 p.m. ET

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The Arizona Cardinals kick off the 2021 NFL regular season on the road against the Tennessee Titans on Sept. 12.  Week 1 represents Arizona’s first chance to show that they have made significant strides after finishing 8-8 in 2020.

The Cardinals defense will be tested by star offensive talent like running back Derrick Henry, plus Tennessee’s latest addition, two-time All-Pro wide receiver Julio Jones. He will be flanked by physical Titans wideout A.J. Brown, who is coming off of an 11-touchdown season.

Arizona’s defense was top-10 in the league in yards per attempt last year. This will be a key for the Cardinals, as the Titans’ punishing running game opens up play-action opportunities for Ryan Tannehill.

In a matchup between two physical teams that can eat up yardage on the ground, opening odds have Tennessee as a slight favorite over Arizona.

Tennessee made perhaps the splashiest move of the NFL offseason in adding Jones, so it comes as no surprise that the public is hammering the Titans’ side of the action. At the time of this writing, 71% of the spread tickets have landed on the Titans.

Arizona bettors who are confident in the Cardinals coming out on top in Week 1 will definitely want to take a look at the moneyline for Cardinals vs. Titans on DraftKings, which has Arizona as a +135 underdog at the time of this writing.

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Arizona Cardinals Betting Trends, Futures

Arizona was 7-9 Against The Spread (ATS) last season, and possessed a slightly better ATS record away from State Farm Stadium at 4-4 on the road.

The Cardinals made some exciting offseason additions themselves, adding defensive end J.J. Watt to a defensive line that already features the dominant Chandler Jones.

And on offense, wideout AJ Green and running back James Conner could firepower to the Arizona offense, even with their extensive injuries histories.

The Action Network’s Sean Koerner projects the spread for Cardinals vs. Titans at Arizona +3.5.

The Action Network’s Stuckey has released his power ratings that have the 49ers winning the division but have the Cardinals even with the Rams and Seahawks behind San Francisco.

Stuckey ultimately stayed away from the NFC West division odds and instead bet on the 49ers to make the postseason. If Arizona bettors believe in this year’s squad having enough talent to win the NFC West, the Cardinals sit as a juicy +650 underdog to win the division at DraftKings.

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