Jaguars vs. Eagles Odds, Predictions, Picks

Philadelphia and Jacksonville are meeting across the Atlantic this week, with the Eagles making the trip to Tottenham Hotspur Stadium for a London date with the Jaguars. Trevor Lawrence and a defense that's quietly become one of the league's most disruptive groups have Jacksonville playing its best football of the season, while Philadelphia, a Super Bowl champion as recently as 2025, is still looking for the version of themselves that dominated that run. Before we dive in, remember to grab a Polymarket promo code, read our Polymarket review, and download the Action Network app for more NFL picks and analysis.

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Let's get into my Eagles vs. Jaguars prediction and my NFL predictions for Week 5.

SPREAD

Jacksonville opened as more than a touchdown favorite here, and the number has held at Jaguars -7.5. That's a wide gap for a matchup between two 2025 playoff teams, but it tracks with how differently these two sides have looked through four weeks: Jacksonville's defense ranks among the league's best, while Philadelphia's offense, even with Hurts, Brown and Saquon Barkley, has yet to find consistency. Even so, the Jaguars -7.5 price is close to even money on Polymarket, suggesting the market isn't fully sold on a blowout.

MONEYLINE

The gap widens on the moneyline. Jacksonville's price makes the Jaguars heavy favorites, in line with a team expected to win roughly three times out of four. Philadelphia carries the weight of a strong recent run in this series, but neither has shown up in the results through four weeks, and the market has taken notice.

TOTAL

At 42.5 points, this total sits on the lower end for a Week 5 game, a fair reflection of Jacksonville's defense and an Eagles offense still finding its footing. Trading here has been much lighter than on the spread or moneyline, but the early lean points toward the Under, with both teams likely wanting to control the clock early, given the unusual 9:30 a.m. ET window.

My Pick: Jaguars -7.5

• Eagles-Jaguars Point Spread: Jaguars 50¢
• Eagles-Jaguars Total: Over/Under 42.5
• Eagles-Jaguars Moneyline: Eagles 24¢· Jaguars 76¢

NFL 2026 Week 5 Picks

Jacksonville arrives in form, fresh off wins over New England and Cincinnati behind Trevor Lawrence and a defense that's quickly become one of the league's stingiest. Philadelphia is still searching for its footing after a Week 4 loss to the Rams.

Jacksonville's defense has quietly turned into one of football's toughest units, holding New England to single digits in Week 3 and then outlasting a huge day from Joe Burrow in Week 4. Two-way standout Travis Hunter has given that side even more juice on both ends of the field. That identity travels well against an Eagles offense that hasn't found its rhythm through four games, even with A.J. Brown and Jalen Hurts back in the lineup. On Polymarket, the moneyline makes Jacksonville a clear favorite, but the spread is priced far closer to even, and that gap is worth trading. History still leans Eagles, who have won 5 of the last 6 meetings in this series, but this season's form points the other way. Jacksonville covering looks like the stronger angle than simply picking the Jaguars to win outright.

Pick: Jaguars

• Jacksonville is pulling the heavier share of activity on the spread, with the market pricing the Jaguars close to even money to cover.
• Trading on the total has been much lighter than the other two markets, with what little volume there is leaning toward the Under.
• On the moneyline, the clear majority of activity sits behind Jacksonville, reflected in a price that makes the Jaguars heavy favorites.

Philadelphia Eagles vs. Jacksonville Jaguars is scheduled for 9:30 AM ET, live from Tottenham Hotspur Stadium in London, England. The game is live on NFL Network.