Liverpool hosts Villarreal at Anfield in England for a Champions League group stage clash on Tuesday, October 20, with kickoff scheduled for 3:00 p.m. ET.
The Reds have a perfect record in the competition so far, while the Spanish side looks to build on a crucial Matchday 2 victory.
Liverpool is favored by -200 on the moneyline and -1.5 on the goal line. Villarreal is +475 on the moneyline and +1.5 on the goal line. The total is set at 3.5 goals.
Let’s get into our Liverpool vs Villarreal prediction.
Villarreal vs Liverpool Prediction
Our Villarreal vs Liverpool best bet is for Liverpool to secure the win while both teams find the back of the net. The Reds' potent attack should be too much for Villarreal at Anfield, but the visitors' defensive vulnerabilities suggest they can find the net.
Villarreal vs Liverpool Odds

Villarreal vs Liverpool Betting Analysis
Under Andoni Iraola, Liverpool is expected to control the tempo of this match. His tactical approach emphasizes a high press, which has already placed them among the Premier League's elite for fewest passes allowed per defensive action. This aggressive style should force Villarreal into difficult situations and limit their time on the ball. Historically, the Spanish club has struggled with possession in Champions League away fixtures, averaging just 43% of the ball since the start of last season. Liverpool should dominate possession and create numerous scoring opportunities.
The underlying data strongly supports a Liverpool victory. In their last seven Champions League home games, the Reds have generated a higher expected goals (xG) figure than their opponents in every single match, averaging an impressive 3.14 xG for versus just 0.8 xG against. This demonstrates their consistent ability to create high-quality chances at Anfield while suppressing their opponents.
The head-to-head record also favors the home side. Liverpool and Villarreal last met in the 2021-22 Champions League semifinals, where Liverpool advanced after winning both legs. The Reds are currently on a three-match winning streak against Villarreal. While only one of their four all-time meetings saw both teams score, the current attacking form of both clubs suggests a departure from that trend is likely. Liverpool's experience and home-field advantage should ultimately be the deciding factors in this contest.
Check out the best soccer odds before making your Liverpool vs Villarreal picks.
Villarreal vs Liverpool Picks
- Liverpool to Win and Both Teams to Score (+180, bet365)
- Both Teams to Score and Over 2.5 Goals (-105, bet365)
Despite dealing with several key injuries, Liverpool's offense has remained formidable. They demonstrated their depth by scoring six goals against LASK in their last European outing, even without regulars like Alexander Isak and Dominik Szoboszlai. However, that same match exposed defensive frailties, as they conceded three times. We expect manager Andoni Iraola to restore Virgil van Dijk to the starting lineup, but the team's high-press system can still leave them open to counter-attacks.
Villarreal's attack has undergone a significant transformation under manager Inigo Perez. After failing to score a single away goal in the Champions League last season, they have already netted twice on the road against Dortmund and put three past Napoli in this campaign. This newfound offensive confidence suggests they have the quality to trouble Liverpool's defense.
While winning at Anfield is a monumental task, getting a goal seems very achievable. Liverpool already defeated a strong Spanish opponent, Atletico Madrid, 2-1 at home on Matchday 1, and a similar scoreline could be in the cards here, making the Liverpool vs Villarreal pick of a home win with both teams scoring an attractive option.
Villarreal vs Liverpool Predicted Lineups
Liverpool Predicted Lineup
Alisson Becker; Araujo, Jacquet, Van Dijk, Kerkez; Szoboszlai, Mac Allister; Barcola, Wirtz, Ngumoha; Isak
Villarreal Predicted Lineup
Luiz Junior; Mourino, Pau Navarro, Veiga, Romero; Saliba, Santi Comesana, Gueye, Alberto Moleiro; Gerard Moreno, Mikautadze













