The 2026-27 Premier League season is here and Gameweek 1 is in the books.
Three picks this week with clear angles from the opening weekend. Let’s get into it.
Below, I’ll break down my top three Premier League best bets for Gameweek 2.
Premier League Best Bets
The club logos in the table below represent each match that our soccer betting staff is targeting from today's games. Click on the team logos for any of the matchups below to navigate to a specific bet discussed in this article.
| Match | Time (ET) | Pick |
|---|---|---|
  | 3:00 p.m. | |
  | 9:00 a.m. | |
  | 9:00 a.m. | |
Specific betting recommendations come from the sportsbook offering preferred odds as of writing. Always shop for the best price using our soccer Odds page, which automatically surfaces the best lines for every game. | ||
Manchester City vs Crystal Palace
Enzo Maresca's Man City managerial debut was far from convincing. They needed a late comeback to beat Bournemouth 2-1 at the Etihad, but Crystal Palace are the right opponent to find their rhythm.
Palace lost 2-0 to Everton on Matchday 1 and have seen significant squad turnover this summer.
City have too much quality at every position, and Maresca will demand a much better performance on the road at Selhurst Park. Back City to deliver.
Pick: Manchester City Moneyline (-350)
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Brentford vs Leeds
Two teams built to score — and in Leeds’ case, built to concede too. Leeds won 1-0 at Nottingham Forest on Matchday 1 in a scrappy affair, but showed defensive vulnerability throughout last season.
Brentford were dominant, beating Tottenham 3-0 and looking every bit the top-10 side they are under Keith Andrews.
At Elland Road with a fired-up home crowd, this game has goals written all over it.
Pick: Over 2.5 Goals (-112)
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Brighton vs Chelsea
Brighton put 4 past Aston Villa. Chelsea put 3 past Fulham. These are two of the most attack-minded sides in the Premier League, facing each other in what should be an open, end-to-end match.
Brighton’s attack is firing on all cylinders, and Chelsea’s quality under Xabi Alonso is undeniable, even if the defense remains suspect.
Both teams to score is almost a given, and getting over 2.5 goals alongside it at -130 is simply a smart number. This is the pick of the weekend.
Pick: Both Teams to Score & Over 2.5 Goals (-130)
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