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Atletico vs Tottenham Prediction, Pick, Champions League Odds (Wednesday, March 18)

Atletico vs Tottenham Prediction, Pick, Champions League Odds (Wednesday, March 18) article feature image
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Pictured: Julian Alvarez, Giuliano Simeone

Atletico Madrid (4-2-1) and Tottenham Hotspur (4-1-2) will face off today at 4:00 p.m. EDT at Tottenham Hotspur Stadium in London, England.

Atlético is favored at a +150 price, with the over/under set at 2.5 (-163o / +130u) goals.

Let's get into my Atlético vs. Tottenham prediction.

Atlético vs. Tottenham Prediction

Pick: Over 2.75 Goals & Both Teams to Score
My Atlético vs. Tottenham best bet is for the match to feature plenty of goals on both sides.

Atlético vs. Tottenham Odds

Atlético Logo
Wednesday, March 18, 2026
4:00 p.m. EDT
-
Tottenham Logo
Atlético Odds
SpreadTotalMoneyline
-0.5
+138
2.5
-163o / +130u
+150
Tottenham Odds
SpreadTotalMoneyline
+0.5
-200
2.5
-163o / +130u
+155
Odds via DraftKings. Get up-to-the-minute SOCCER odds here.
DraftKings Logo

Atlético vs. Tottenham Picks, Parlay

Leg 1: Over 2.75 Goals
Leg 2: Both Teams to Score

The first leg of this tie ended in a wild 5-2 victory for Atletico Madrid, a match where Spurs collapsed defensively in the opening 22 minutes. While a comeback seems historically improbable, Tottenham will be playing for pride and to give their home fans something to cheer about. This sets the stage for an open and attacking game.

Atletico Madrid’s defensive solidity, a former trademark under Diego Simeone, has vanished this season. They finished the Champions League group stage with the worst defensive record among the top 16 clubs, conceding 15 goals. Their matches in the competition have averaged an incredible 4.55 goals per game, with scorelines of 3-3, 4-1 and 5-2 in the knockout stages alone. Furthermore, 10 of their 11 Champions League matches have seen both teams score.

While Spurs have a dreadful record against Spanish clubs—winning only three of 16 European encounters—their situation forces them to attack from the start. Atletico has also struggled on the road, securing only four wins in 13 away league matches this season and just one away victory in five Champions League attempts. Given these factors, another high-scoring affair seems likely, making the Over 2.75 goals a strong play.

Playbook

Atlético vs. Tottenham Projections

Projected Chance of Winning

AtléticoDrawTottenham
34.1%22.6%43.3%

Projected Total Goals

AtléticoTotal GoalsTottenham
1.342.891.55

Atlético vs. Tottenham Betting Analysis

Atletico Madrid effectively sealed its passage to the next round with a four-goal blitz in the first 22 minutes of the first leg. However, Tottenham showed some fight in the latter stages of that match, indicating it won't simply roll over at home. The primary focus for Spurs remains Premier League survival, as they hover precariously above the relegation zone. This might mean they won't exhaust themselves chasing an unlikely comeback, but an early goal could inject life into the stadium and put pressure on the visitors.

Spurs have been excellent at home in the Champions League, winning all four matches this season while keeping clean sheets in each. They are also unbeaten in their last 24 UEFA fixtures on home soil. Despite this strong home form, history is against them; only four of 51 teams that lost a Champions League knockout first leg by three or more goals have ever advanced.

The head-to-head history is brief, with the recent 5-2 result being the first competitive meeting. Atletico has a solid record against English clubs in Europe (14 wins, 12 draws, 10 defeats), while Tottenham has struggled against Spanish opposition (2 wins, 5 draws, 8 defeats). With Atletico’s progression all but secured, the dynamic of this match points toward an entertaining contest rather than a tactical stalemate.

Check out the best soccer odds before making your Tottenham vs Atletico Madrid picks.

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