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Manchester City vs Napoli Prediction, Pick, Champions League Odds

Manchester City vs Napoli Prediction, Pick, Champions League Odds article feature image
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Pep Guardiola (Imagn Images)

SSC Napoli and Manchester City will face off today at 3:00 p.m. EDT at Etihad Stadium in Manchester, England.

Man City is favored at a -150 price, with the over/under set at 2.5 (-139o / +109u) goals.

Let's get into my Napoli vs. Man City prediction.

Quickslip

Napoli vs. Man City Prediction

Pick: Manchester City To Win
My Napoli vs. Man City best bet is Manchester City to take the win.

Napoli vs. Man City Odds

Napoli Logo
Thursday, September 18, 2025
3:00 p.m. EDT
-
Man City Logo
Napoli Odds
SpreadTotalMoneyline
+0.5
+120
2.5
-139o / +109u
+400
Man City Odds
SpreadTotalMoneyline
-0.5
-165
2.5
-139o / +109u
-150
Odds via bet365. Get up-to-the-minute CHAMPIONS odds here.
bet365 Logo

Napoli vs. Man City Projections

Projected Chance of Winning

NapoliDrawMan City
16.7%21.9%61.4%

Projected Total Goals

NapoliTotal GoalsMan City
0.732.381.65

Napoli vs. Man City Betting Analysis

Napoli makes their anticipated return to the Champions League stage with a daunting opening fixture against Manchester City at the Etihad Stadium.

The reigning Italian champions hold a perfect record in Serie A so far, and now they face the task of taking on Pep Guardiola’s side, which recently restored confidence with a 3-0 win over Manchester United in the derby.

Pep Guardiola’s new-look squad has looked deadly at times, and we are backing them to win and concede a goal or less as part of our Manchester City vs Napoli predictions.

The Citizens’ home form is excellent. They have suffered just five defeats in their last 25 matches at the Etihad, despite enduring a tough 2024/25 campaign. During that run, City have scored an average of 2.56 goals per game and conceded just 1.20.

Pep’s team stormed to a 3-0 lead in the Manchester Derby on Sunday. They finished the game with an xG of 2.63 and managed to keep a clean sheet. The result will give them confidence coming into this game.

Napoli are 5.00/+400 to win on Thursday, and they have struggled in recent matches where they have been priced similarly. In their last five outings at odds of 4.00/+300 or greater, they have lost three, drawn two, and scored just three goals.

Such a poor attacking output as the underdog doesn’t bode well ahead of the trip to the Etihad.

Napoli vs. Man City Projected Starting Lineups

Napoli

Milinkovic-Savic; Di Lorenzo, Beukema, Buongiorno, Spinazzola; Lobotka; Politano, Anguissa, De Bruyne, McTominay; Hojlund

Man City

Donnarumma; Lewis, Dias, Gvardiol, Ake; Rodri, Gonzalez; Savinho, Foden, Doku; Haaland

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