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Newcastle vs Barcelona Prediction, Pick, Odds for Champions League on September 18

Newcastle vs Barcelona Prediction, Pick, Odds for Champions League on September 18 article feature image
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Barcelona and Newcastle United will face off today at 3:00 p.m. EDT at St. James' Park in Newcastle, England.

Barcelona is favored at a +135 price, with the over/under set at 3.5 (+110o / -150u) goals.

Let's get into my Barcelona vs. Newcastle prediction.

Barcelona vs. Newcastle Betting Analysis

Newcastle United kicks off its Champions League campaign with a mouthwatering home clash against Barcelona. The clash is significantly overshadowed by key absences due to injuries, which are expected to have a profound impact on the game's dynamics.

Hansi Flick’s team opened as heavy favourites in the Newcastle vs Barcelona odds, but injuries have seen them drift to 2.25/+125. The most notable absence is that of Lamine Yamal, while Gavi and Frankie de Jong might start from the bench.

However, the same stories were wrapped around the Valencia game, but dominated 6-0. The team doesn’t seem troubled by a few absences and continues to write impressive results.

We can’t underestimate Edie Howe’s team, despite the lack of results. After four games, the Magpies have only five points to show, with their 1-0 win over Wolves being their first win. But, they remain a constant threat, as was seen in their 3-2 loss against Liverpool.

Our internal data projection model, BETSiE, reinforces confidence in a Barcelona victory by predicting a superior expected goal output of 1.85 xG compared to Newcastle’s 1.42 xG. BETSiE also gives the away side a 49.1% chance of winning.

Barcelona vs. Newcastle Odds

Barcelona Logo
Thursday, September 18, 2025
3:00 p.m. EDT
-
Newcastle Logo
Barcelona Odds
SpreadTotalMoneyline
-0.5
+115
3.5
+110o / -150u
+135
Newcastle Odds
SpreadTotalMoneyline
+0.5
-175
3.5
+110o / -150u
+180
Odds via bet365. Get up-to-the-minute CHAMPIONS odds here.
bet365 Logo