The Cleveland Guardians host the Houston Astros on April 20, 2026. First pitch from Progressive Field is scheduled for 6:10 p.m. EDT. The game will be broadcast on CLEG.
The Guardians are favored by -118 on the moneyline. The Astros are +100 on the moneyline. The total is set at 7.5 runs.
Find my MLB picks and Astros vs Guardians prediction below, as well as probable pitchers, weather report, and more.
Astros vs Guardians Prediction
- Astros vs Guardians Pick: Under 7.5
My Astros vs Guardians best bet is on the Under. Make sure to find the best odds by checking our live MLB odds page.
Astros vs Guardians Odds
| Astros Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-1.5 +168 | 7.5 -106o / -114u | +100 |
| Guardians Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+1.5 -205 | 7.5 -106o / -114u | -118 |
- Astros vs Guardians moneyline: Astros +100, Guardians -118
- Astros vs Guardians over/under: 7.5 (-106 / -114)
- Astros vs Guardians spread: Astros -1.5 (+168), Guardians +1.5 (-205)
Astros vs Guardians Probable Pitchers
| Spencer Arrighetti (RHP) | Stat | Slade Cecconi (RHP) |
|---|---|---|
| 1-0 | W-L | 0-2 |
| 0.2 | fWAR (FanGraphs) | 0.0 |
| 1.50 / 4.19 | ERA / xERA | 5.03 / 5.04 |
| 2.80 / 3.94 | FIP / xFIP | 5.26 / 4.74 |
| 1.17 | WHIP | 1.37 |
| 22.2% | K-BB% | 9.1% |
| 45.5% | GB% | 48.2% |
| 100 | Stuff+ | 93 |
| 87 | Location+ | 91 |
Astros vs Guardians MLB Betting Preview
When I placed this wager last night, I didn’t even know who was pitching.
This is a Pure Weather Under.
Do you know how cold it’s going to be at Progressive Field on Monday? It’s projected to be 37 degrees at first pitch. It might get even colder in the later innings.
There’s some wind blowing in from left field, but the ball shouldn’t be going far in these conditions. For this game, BallParkPal projects a -26% run-scoring factor behind a -42% home-run factor.
Astros vs Guardians Pick, Betting Analysis
Cleveland’s offense is always the same. The Guardians are likely to continue being a league-average, contact-heavy lineup powered by Jose Ramirez.
However, I believe Houston’s offense is cooling off after a red-hot start. The Astros boast a 124 wRC+ on the season, but that mark is down to 106 over the past two weeks.
I also really like Cleveland’s bullpen and defense. Even if I can’t say the same for Houston, there’s enough in this matchup for me to bet the Under.
Pick: Under 7.5
