Cardinals vs. Cubs Odds & Betting Predictions - September 28, 2025

Cardinals at Cubs

7:20 pm • FDSMW

St. Louis Cardinals

0

0 - 2

Chicago Cubs

2

pitcher		team	era	w-l
J.Assad			3.65	4-1
K.Leahy			3.07	4-2

MatchupOpenSpreadTotalMoneyline
Cardinals 78-84	+1.5	+1.5-181	o7-118	+126
Cubs 92-70	u8.5	-1.5+144	u7-102	-155

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Sunday 7:20 p.m.

September 28, 2025

Wrigley FieldChicago

Cardinals vs Cubs: Who To Back in Toss-up Season Ender
Nick Martin•
Sep 28, 2025 UTC

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MLB Public Betting

Cubs are 4-1 in their last 5 games.
Cubs are 4-1 in their last 5 games against the spread
Cubs are 39-42 in their road games against the spread
The totals have gone OVER in 4 of Cubs' last 5 games
The totals have gone OVER in 40 of Cubs' 81 last games at home

Against the Spread (ATS) History

	overall	home	away	favorite	underdog
Cubs	78-84	39-42	39-42	55-60	22-24
Cardinals	80-82	41-40	39-42	25-42	54-40

Over/Under History

	overall	home o/u	away o/u	favorite o/u	underdog o/u
Cubs	74-78-10	40-36-5	34-42-5	52-56-7	22-21-3
Cardinals	81-74-7	39-39-3	42-35-4	33-29-5	47-45-2

Straight-Up (ML) History

	overall	home	away	favorite	underdog
Cubs	92-70	50-31	42-39	73-42	18-28
Cardinals	78-84	44-37	34-47	33-34	44-50

date	opponent	score	spread	over/under	moneyline
Sep 27th	STL	W 7-3	-1.5 W	O 9.5	CHC -178
Sep 26th	STL	W 12-1	-1.5 W	O 9	CHC -184
Sep 25th	NYM	L 5-8	+1.5 L	O 7.5	NYM -103
Sep 25th	NYM	W 10-3	+1.5 W	O 7.5	CHC -118
Sep 23rd	NYM	L 7-9	+1.5 L	O 7.5	NYM +100

Masyn Winn
IF
Masyn Winn (knee) has been scratched Friday.
Out

Michael Soroka
P
Soroka is out with shoulder
Out
Justin Steele
P
Steele is out for season with elbow
Out for Season

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PITCHER		PC	IP	K	ER
RK.Leahy, P		39	3	1	0
LJ.King, P		18	1.2	2	1
RM.Svanson, P		17	1.1	2	0
RR.Fernandez, P		18	1	2	0

HITTERS	H-AB	R	HR	RBI
1J.Fermin, 2B	0-2	0	0	0
2I.Herrera, DH	0-3	0	0	0
3N.Gorman, 3B	0-3	0	0	0
4T.Saggese, SS	1-3	0	0	0
5J.Walker, RF	0-3	0	0	0
6J.Crooks, C	1-3	0	0	0
7Y.Pozo, 1B	0-3	0	0	0
8V.Scott, CF	2-3	0	0	0
9N.Church, LF	0-2	0	0	0

PITCHER		PC	IP	K	ER
RJ.Assad, P		79	5.1	6	0
RM.Soroka, P		7	0.2	0	0
LJ.Wicks, P		17	1.1	1	0

HITTERS	H-AB	R	HR	RBI
1M.Busch, 1B	0-3	0	0	0
1R.McGuire, C	-
2N.Hoerner, 2B	1-3	0	0	0
2N.Hoerner, SS	1-3	0	0	0
3I.Happ, LF	0-2	0	0	0
3K.Alcantara, LF	1-1	1	0	0
4K.Tucker, DH	0-3	0	0	0
5S.Suzuki, RF	1-3	1	1	1
6M.Ballesteros, C	1-3	0	0	1
6M.Ballesteros, 1B	1-3	0	0	1
7P.Crow-Armstrong, CF	1-3	0	0	0
8D.Swanson, SS	0-1	0	0	0
8J.Turner, PH	0-1	0	0	0
8J.Turner, 3B	0-1	0	0	0
9W.Castro, 3B	0-2	0	0	0
9W.Castro, 2B	0-2	0	0	0

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MatchupOverUnder
Cardinals 78-84	o3.5+112	u3.5-141
Cubs 92-70	o3.5-126	u3.5-102