Cardinals vs. Cubs Odds & Betting Predictions - September 26, 2025
Cardinals at Cubs
6:20 pm • MLB NetworkStarting Pitchers
| pitcher | team | era | w-l | |
|---|---|---|---|---|
 |  | 3.95 | 11-7 | |
 |  | 4.84 | 8-11 |
Cardinals at Cubs Odds
Spread, Total, Moneyline
MatchupOpenSpreadTotalMoneyline | ||||
|---|---|---|---|---|
Cardinals 78-84 | +1.5 | +1.5-126 | o9-103 | +154 |
Cubs 92-70 | u9 | -1.5+105 | u9-118 | -184 |
Wrigley FieldChicago
Cardinals vs. Cubs Expert Picks
Boomer Betz
Last 30d: 129-102-2 (+37.4u)
Under 5 (F5)-114
1u
Allan Lem
Last 30d: 115-116-7 (-5.8u)
Under 9-115
0.58u
Fingers crossed that Miles Mikolas doesn’t implode on us 🤞
Scott Rickenbach
Last 30d: 51-46-2 (-3.0u)
Over 9-102
0.98u
Ryan Sura
Last 30d: 99-93-2 (+7.4u)
N.Hoerner o1.5 Hits + Runs + RBIs-144
1.04u
Sean Zerillo
Last 30d: 146-180-4 (-14.8u)
Under 9-118
0.59u
Bet to -125
Cardinals vs. Cubs Previews & Analysis
Prop Odds Comparison
Line Movement Tracker
Cardinals vs. Cubs Public Betting Percentages
Betting Trends
- Cubs are 4-1 in their last 5 games.
- Cubs are 4-1 in their last 5 games against the spread
- Cubs are 39-42 in their road games against the spread
- The totals have gone OVER in 4 of Cubs' last 5 games
- The totals have gone OVER in 40 of Cubs' 81 last games at home
Matchup History
Against the Spread (ATS) History
Over/Under History
Last 5 Matchups
Cardinals vs. Cubs Injury Updates
Cardinals Injuries
- Masyn WinnIF
Masyn Winn (knee) has been scratched Friday.
Out
Cubs Injuries
- Michael SorokaP
Soroka is out with shoulder
Out
- Justin SteeleP
Steele is out for season with elbow
Out for Season
Cardinals vs. Cubs Box Score
Cardinals Player Stats| PITCHER | PC | IP | K | ER | |
|---|---|---|---|---|---|
 | 79 | 5 | 4 | 4 | |
 | 20 | 1 | 1 | 0 | |
 | 31 | 0.1 | 1 | 5 | |
 | 41 | 1.2 | 1 | 3 |
| HITTERS | H-AB | R | HR | RBI |
|---|---|---|---|---|
 | 0-3 | 0 | 0 | 0 |
 | 1-3 | 0 | 0 | 0 |
 | 0-1 | 0 | 0 | 0 |
| 0-1 | 0 | 0 | 0 |
 | 0-2 | 0 | 0 | 0 |
| 0-1 | 0 | 0 | 0 |
| 0-1 | 0 | 0 | 0 |
 | 0-3 | 0 | 0 | 0 |
 | 0-1 | 0 | 0 | 0 |
| 0-1 | 0 | 0 | 0 |
 | 2-4 | 1 | 0 | 0 |
| 2-4 | 1 | 0 | 0 |
 | 1-4 | 0 | 0 | 0 |
 | 0-4 | 0 | 0 | 0 |
 | 1-3 | 0 | 0 | 1 |
 | 0-3 | 0 | 0 | 0 |
Cubs Player Stats| PITCHER | PC | IP | K | ER | |
|---|---|---|---|---|---|
 | 77 | 5.2 | 7 | 0 | |
 | 11 | 0.1 | 1 | 1 | |
 | 18 | 1 | 3 | 0 | |
 | 10 | 1 | 1 | 0 | |
 | 13 | 1 | 2 | 0 |
| HITTERS | H-AB | R | HR | RBI |
|---|---|---|---|---|
 | 2-3 | 2 | 1 | 2 |
| 1-1 | 1 | 0 | 0 |
| 1-1 | 1 | 0 | 0 |
 | 2-5 | 2 | 1 | 1 |
 | 2-4 | 1 | 0 | 1 |
 | 1-1 | 0 | 0 | 1 |
 | 1-4 | 2 | 0 | 0 |
 | 1-4 | 1 | 1 | 4 |
 | 1-3 | 1 | 1 | 2 |
 | 0-3 | 1 | 0 | 0 |
 | 0-4 | 0 | 0 | 0 |
 | 1-4 | 1 | 0 | 1 |
Cardinals vs. Cubs Odds Comparison
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Cardinals at Cubs Team Totals
MatchupOverUnder | ||
|---|---|---|
Cardinals 78-84 | o3.5-122 | u3.5-106 |
Cubs 92-70 | o4.5-132 | u4.5+103 |