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Cardinals vs. Reds Odds & Betting Predictions - May 22, 2026

Cardinals at Reds

10:40 pm • CINR

St. Louis Cardinals

28-21
@

Cincinnati Reds

26-24
Starting Pitchers
pitcherteameraw-l
Chris Paddack logoC.PaddackCincinnati Reds logo3.600-0
Kyle Leahy logoK.LeahySt. Louis Cardinals logo3.945-3

Cardinals at Reds Odds

Spread, Total, Moneyline

MatchupOpenSpreadTotalMoneyline
Cardinals
28-21
+1.5
-1.5+150
o9.5-109
-110
Reds
26-24
u9.5
+1.5-177
u9.5-110
-110
location pinFriday 10:40 p.m.
May 22, 2026
Great American Ball ParkCincinnati
thermometer image67°Fahrenheit
rain image80%Rain
wind image7Wind
Cardinals vs. Reds Expert Picks
Frank Ammirante
Frank Ammirante
Last 30d: 250-266-10 (-8.2u)
Under 9.5-110
1.1u

Prop Odds Comparison

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No props found

Line Movement Tracker

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Cardinals vs. Reds Public Betting Percentages

Away Logo

Cardinals

Public

Home Logo

Reds

49%

Bets%

51%

Money%

MLB Public Betting Right Arrow

Betting Trends

  • Reds are 2-3 in their last 5 games.
  • Reds are 2-3 in their last 5 games against the spread
  • Reds are 16-10 in their road games against the spread
  • The totals have gone OVER in 3 of Reds' last 5 games
  • The totals have gone OVER in 17 of Reds' 24 last games at home

Matchup History

Against the Spread (ATS) History

overallhomeawayfavoriteunderdog
Reds		29-2113-1116-109-620-15
Cardinals		30-1915-1115-83-327-16

Over/Under History

overallhome o/uaway o/ufavorite o/uunderdog o/u
Reds		31-18-117-714-11-110-521-13-1
Cardinals		22-24-313-12-19-12-22-420-20-3

Straight-Up (ML) History

overallhomeawayfavoriteunderdog
Reds		26-2413-1113-139-617-18
Cardinals		28-2113-1315-83-325-18

Last 5 Matchups

dateopponentscorespreadover/undermoneyline
May 20th@PHIW 9-4+1.5 WO 9.5CIN +129
May 19th@PHIW 4-1+1.5 WU 8.5CIN +122
May 18th@PHIL 4-5-1.5 LU 10PHI +104
May 17th@CLEL 3-10+1.5 LO 8.5CLE +135
May 16th@CLEL 4-7+1.5 LO 8.5CLE +125

Reds vs. Cardinals Injury Updates

Reds Injuries

  • Hunter Greene
    SP

    Greene is out with elbow

    Out

Cardinals Injuries

  • Lars Nootbaar
    LF

    Nootbaar is out with heel

    Out

  • Nathan Church
    LF

    Nathan Church has been scratched Thursday.

    Out

See more MLB Injuries Right Arrow
Cardinals vs. Reds Starting Lineups
Cardinals Starting Lineup
Projected
PITCHERW-LERAWHIPK/9
Kyle Leahy logoRK.Leahy, P5-33.941.5556.70
HITTERSAVGOBPSLGHR
JJ Wetherholt logo1J.Wetherholt, 2B.239.357.4139
Ivan Herrera logo2I.Herrera, DH.262.386.4266
Alec Burleson logo3A.Burleson, 1B.290.359.4687
Jordan Walker logo4J.Walker, RF.295.366.56313
Nolan Gorman logo5N.Gorman, 3B.228.313.3676
Masyn Winn logo6M.Winn, SS.245.328.3401
Pedro Pages logo8P.Pages, C.219.265.3624
Victor Scott logo9V.Scott, CF.185.240.2612
Reds Starting Lineup
Projected
PITCHERW-LERAWHIPK/9
Chris Paddack logoRC.Paddack, P0-03.601.4005.40
HITTERSAVGOBPSLGHR
Matt McLain logo1M.McLain, 2B.208.309.3435
Elly De La Cruz logo2E.De La Cruz, SS.290.356.52511
JJ Bleday logo3J.Bleday, LF.299.402.6366
Sal Stewart logo4S.Stewart, 3B.265.353.50312
Spencer Steer logo5S.Steer, 1B.273.340.4487
Nathaniel Lowe logo6N.Lowe, DH.260.330.5106
Will Benson logo7W.Benson, RF.171.315.3032
Tyler Stephenson logo8T.Stephenson, C.183.291.2923
TJ Friedl logo9T.Friedl, CF.178.258.2602

Cardinals vs. Reds Odds Comparison

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Cardinals at Reds Team Totals

MatchupOverUnder
Cardinals
28-21
N/A
N/A
Reds
26-24
N/A
N/A